Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review

(1) Background: Extrapleural solitary fibrous tumors (ESFTs) are rare oncological entities occurring in the head and neck, and even more so in the salivary glands. The clinical presentation and histologic features are usually unspecific, resulting in frequent misclassification. As an unusual tumor,...

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Published inDiagnostics (Basel) Vol. 12; no. 11; p. 2688
Main Authors Boschetti, Ciro Emiliano, Vitagliano, Rita, Imola, Gianmaria, Cornacchini, Nicola, Colella, Maria Luisa, Tartaro, Gianpaolo, Colella, Giuseppe
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2022
MDPI
Subjects
Antibiotics
Case Report
Diagnosis
Exocrine glands
Laboratories
Lymphatic system
malignancies
Maxillofacial surgery
Mesothelioma
parotid gland
Population
salivary gland
Salivary gland tumors
solitary extrapleural fibrous tumor
Steroids
sublingual gland
submandibular gland
Sutures
Tumors
Italy
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Summary:(1) Background: Extrapleural solitary fibrous tumors (ESFTs) are rare oncological entities occurring in the head and neck, and even more so in the salivary glands. The clinical presentation and histologic features are usually unspecific, resulting in frequent misclassification. As an unusual tumor, ESTFs have an unpredictable clinical behavior. (2) Methods: We present two clinical cases referred to our Maxillofacial Surgery Unit for the onset of a symptomless mass involving, in one case, the parotid gland, and in the other case, the sublingual gland. (3) Results: Solitary fibrous tumors could be considered as neoplasms with intermediate biological behavior that are not entirely predictable on the basis of morphological features, as these are mostly still unknown. However, a few histologic, immunohistochemical, and imaging features, such as a hypodense signal at the T1 sequence in an MRI, or positivity for CD34, bcl2, and CD99, and the NAB2-STATS6 fusion gene, could be useful for an early differential diagnosis of ESTFs. (4) Conclusions: All patients were alive at follow-up with no evidence of disease. Surgical management should always be considered as the first choice for oncological radicality, and clinical behavior should always be defined with the help of the study of radiological and anatomopathological features.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12112688