High prevalence of COPD in atherosclerosis patients

• Published in: International journal of chronic obstructive pulmonary disease Vol. 12; pp. 3047 - 3053
• Main Authors: Tuleta, Izabela, Farrag, Tarik, Busse, Laura, Pizarro, Carmen, Schaefer, Christian, Pingel, Simon, Nickenig, Georg, Skowasch, Dirk, Schahab, Nadjib
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Dove Medical Press Ltd; Dove Medical Press
• Subjects: Abbreviations; Aged; Aged, 80 and over; Anemia; Anemia - epidemiology; Asthma; Atherosclerosis; Autoimmune diseases; Biomarkers - blood; Blood pressure; Body mass index; Carbon monoxide; Cardiovascular disease; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Comorbidity; COPD; Cytokines; Diabetes; diabetes mellitus; Diabetes Mellitus - epidemiology; Diagnosis; Female; Forced Expiratory Volume; Germany - epidemiology; Humans; Hypertension; inflammation; Inflammation - epidemiology; Inflammation Mediators - blood; Intracranial Arteriosclerosis - blood; Intracranial Arteriosclerosis - diagnosis; Intracranial Arteriosclerosis - epidemiology; Lung - physiopathology; Lung diseases; Male; Middle Aged; Original Research; Patients; Peripheral Arterial Disease - blood; Peripheral Arterial Disease - diagnosis; Peripheral Arterial Disease - epidemiology; Prevalence; Prevalence studies (Epidemiology); Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - physiopathology; Risk Factors; Statistical analysis; Ultrasonic imaging; Vein & artery diseases; Vital Capacity; Germany; lung function; peripheral artery disease; inflammation; diabetes mellitus; interleukin-8; capillary blood gas; anemia; cerebral artery disease
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S141988

Atherosclerosis and COPD are both systemic inflammatory diseases that may influence each other. The aim of the present study was to determine the prevalence of COPD in patients with cerebral and/or peripheral artery disease and to assess factors associated with the presence of COPD. Following the diagnosis of cerebral and/or peripheral artery disease by means of duplex sonography, 166 consecutive patients underwent body plethysmography with capillary blood gas analysis. Thereafter, blood tests with determination of different parameters such as lipid profile, inflammatory and coagulation markers were conducted in remaining 136 patients who fulfilled inclusion criteria of the study. Thirty-six out of 136 patients suffered from COPD, mostly in early stages of the disease. Residual volume indicating emphysema was increased (162.9%±55.9% vs 124.5%±37.0%, <0.05) and diffusion capacity was decreased (55.1%±19.5% vs 75.3%±18.6%, <0.05) in COPD patients vs non-COPD group. In capillary blood gas analysis, COPD patients had lower partial pressure of oxygen (70.9±11.5 vs 75.2±11.0 mmHg, <0.05) and higher partial pressure of carbon dioxide (36.8±7.5 vs 34.4±4.4 mmHg, <0.05) compared with non-COPD individuals. Presence of COPD was associated with predominance of diabetes mellitus, interleukin-8-related systemic neutrophilic inflammation and anemia. In conclusion, COPD is highly prevalent in patients with atherosclerotic artery disease.