Protective Action of Ostreococcus tauri and Phaeodactylum tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

• Published in: Marine drugs Vol. 18; no. 1; p. 3
• Main Authors: Goff, Manon Le, Delbrut, Antoine, Quinton, Marie, Pradelles, Rémi, Bescher, Maelle, Burel, Agnès, Schoefs, Benoît, Sergent, Odile, Lagadic-Gossmann, Dominique, Ferrec, Eric Le, Ulmann, Lionel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.12.2019; MDPI
• Subjects: Algae; Antioxidants; Apoptosis; Apoptosis - drug effects; Aquatic microorganisms; Aromatic compounds; Aromatic hydrocarbons; Benzo(a)pyrene; Benzo(a)pyrene - toxicity; Biocompatibility; Biological activity; Biological Products - pharmacology; Cancer; Cardiovascular diseases; Carotenoids; Cell Line; Cell Survival - drug effects; Cytochrome P-450 CYP1A1 - metabolism; Cytochrome P450; Cytokines; Cytokines - drug effects; Cytotoxicity; Disease prevention; Endothelial Cells; Extracellular; Extracellular vesicles; Extracellular Vesicles - drug effects; Extracellular Vesicles - ultrastructure; Fatty acids; Food; Human diseases; Humans; Hydrocarbons; Inflammation; Interleukin 1; Interleukin 8; Life Sciences; Metabolism; Metabolites; Microalgae; Microalgae - chemistry; Microorganisms; Oceans and Seas; Phytoplankton; Pigments; Pollutants; Polycyclic aromatic hydrocarbons; Polyunsaturated fatty acids; Pyrene; Receptors; Toxicity; United States > US; endothelial cells; benzo[a]pyrene; cell viability; extracellular vesicles; Ostreococcus tauri; Phaeodactylum tricornutum; cytokines; cell protection; aryl hydrocarbon receptor; mRNA expression

Marine microalgae are known to be a source of bioactive molecules of interest to human health, such as n-3 polyunsaturated fatty acids (n-3 PUFAs) and carotenoids. The fact that some of these natural compounds are known to exhibit anti-inflammatory, antioxidant, anti-proliferative, and apoptosis-ind...