Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology

• Published in: Acta pharmacologica Sinica Vol. 36; no. 1; pp. 24 - 31
• Main Authors: Ikeda, Kazuhiro, Horie-Inoue, Kuniko, Inoue, Satoshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2015; Nature Publishing Group
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; breast; Breast Neoplasms - genetics; cancer; DNA-Binding Proteins - genetics; estrogen; Estrogens - genetics; Female; gene; Gene Expression Regulation, Neoplastic - genetics; high-throughput; High-Throughput Nucleotide Sequencing - methods; hormone; Humans; Immunology; Internal Medicine; Medical Microbiology; nuclear; Pharmacology/Toxicology; receptor; Receptors, Estrogen - genetics; Review; sequencing; steroid; technique; transcription; Vaccine; nuclear receptor; breast cancer; steroid hormone; estrogen; gene transcription; high-throughput sequencing technique
• ISSN: 1671-4083; 1745-7254; 1745-7254
• DOI: 10.1038/aps.2014.123

Estrogens are important endocrine hormones that control physiological functions in reproductive organs, and play a pivotal role in the generation and progression of breast cancer. Therapeutic drugs including anti-estrogen and aromatase inhibitors are used to treat patients with breast cancer. The estrogen receptors, ERa and ERβ, function as hormone-dependent transcription factors that directly regulate the expression of their target genes. Therefore, a better understanding of the function and regulation of estrogen-responsive genes provides insight into the gene regulation network associated with breast cancer. Recent technological developments in high- throughput sequencing have enabled the genome-wide identification of estrogen-responsive genes. Further elucidating the estrogen gene cascade is critical for advancements in the diagnosis and treatment of breast cancer.