Single subject analyses reveal consistent recruitment of frontal operculum in performance monitoring

• Published in: NeuroImage (Orlando, Fla.) Vol. 133; pp. 266 - 278
• Main Authors: Amiez, Céline, Wutte, Magdalena G., Faillenot, Isabelle, Petrides, Michael, Burle, Boris, Procyk, Emmanuel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016; Elsevier Limited; Elsevier
• Subjects: Adult; Anterior insula; Brain Mapping - methods; Cognitive science; Feedback; Feedback, Physiological - physiology; Female; fMRI; Frontal Lobe - physiology; Frontal operculum; Human; Humans; Male; Medical imaging; Methods; Morphology; Nerve Net - physiology; Neurofeedback - methods; Neuroscience; Recruitment, Neurophysiological - physiology; Reproducibility of Results; Sensitivity and Specificity; Studies; Task Performance and Analysis; Human; fMRI; Feedback; Anterior insula; Frontal operculum
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2016.03.003

There are continuing uncertainties regarding whether performance monitoring recruits the anterior insula (aI) and/or the frontal operculum (fO). The proximity and morphological complexity of these two regions make proper identification and isolation of the loci of activation extremely difficult. The use of group averaging methods in human neuroimaging might contribute to this problem. The result has been heterogeneous labeling of this region as aI, fO, or aI/fO, and a discussion of results oriented towards either cognitive or interoceptive functions depending on labeling. In the present article, we adapted the spatial preprocessing of functional magnetic resonance imaging data to account for group averaging artifacts and performed a subject-by-subject analysis in three performance monitoring tasks. Results show that functional activity related to feedback or action monitoring consistently follows local morphology in this region and demonstrate that the activity is located predominantly in the fO rather than in the aI. From these results, we propose that a full understanding of the respective role of aI and fO would benefit from increased spatial resolution and subject-by-subject analysis. •Whether aI or fO or both are involved in performance monitoring is debated.•Relationship between local morphology and activity was assessed on an individual subject basis.•Results show that performance monitoring-related functional activity is located in fO.•Local anatomy in this region is a useful tool to disentangle activity issued from aI versus fO.