Genetic polymorphism and chronic obstructive pulmonary disease

• Published in: International journal of chronic obstructive pulmonary disease Vol. 12; pp. 1385 - 1393
• Main Authors: Yuan, Cunhua, Chang, De, Lu, Guangming, Deng, Xiaowei
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Dove Medical Press Ltd; Dove Medical Press
• Subjects: Airway management; Apoptosis - genetics; Chromosomes; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; COPD;Genetic polymorphism; Development and progression; Emphysema; Enzymes; Epigenesis, Genetic; Gene loci; Genetic aspects; Genetic Markers; Genetic polymorphisms; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Genotype & phenotype; Health aspects; Humans; Lung - pathology; Lung - physiopathology; Lungs; MicroRNAs; Mutation; Pathogenesis; Phenotype; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Proteins; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - physiopathology; Review; Risk Factors; Signal transduction; Smoking; China; United Kingdom > UK; South Korea; genetic polymorphism; genome-wide association study; COPD; chronic obstructive pulmonary disease
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S134161

Chronic obstructive pulmonary disease (COPD) is a common chronic disease, and its morbidity and mortality are increasing. There are many studies that have tried to explain the pathogenesis of COPD from genetic susceptibility, to identify the susceptibility of COPD factors, which play a role in early prevention, early detection and the early treatment. However, it is well known that COPD is an inflammatory disease characterized by incomplete reversible airflow limitation in which genes interact with the environment. In recent years, many studies have proved gene polymorphisms and COPD correlation. However, there is less research on the relationship between COPD and genome-wide association study (GWAS), epigenetics and apoptosis. In this paper, we summarized the correlation between gene level and COPD from the following four aspects: the GWAS, the gene polymorphism, the epigenetics and the apoptosis, and the relationship between COPD and gene is summarized comprehensively.