Development and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications

• Published in: Drug design, development and therapy Vol. 15; pp. 4213 - 4226
• Main Authors: Sulastri, Evi, Zubair, Muhammad Sulaiman, Lesmana, Ronny, Mohammed, Ahmed Fouad Abdelwahab, Wathoni, Nasrul
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2021; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Algae; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; antimicrobial; Antimicrobial agents; antioxidant; Antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacology; Bandages; Biological products; Biomaterials; Biomedical materials; Biopolymers; Boric acid; Boric Acids - chemistry; Calorimetry; Caustic soda; Cellulase; Chemistry, Pharmaceutical; Coliforms; Cross-Linking Reagents - chemistry; Crosslinking; Differential scanning calorimetry; E coli; Ethanol; Fourier analysis; Fourier transforms; Free radicals; Glycerin; Glycerol; Glycerol - chemistry; Gram-negative bacteria; Gram-Negative Bacteria - drug effects; Gram-positive bacteria; Gram-Positive Bacteria - drug effects; Heparan sulfate; hydrogel films; Hydrogels; Hydroxides; Hydroxyl radicals; Laboratories; Mechanical properties; Medical dressings; Moisture content; Natural polymers; Original Research; Plasticizers - chemistry; Polymers; Polysaccharides; Polysaccharides - administration & dosage; Polysaccharides - pharmacology; Pseudomonas aeruginosa; Saccharides; Scanning electron microscopy; Seaweeds; Sulfates; Swelling; Thermogravimetric analysis; ulvan; Viscosity; Water content; Water vapor; wound dressing; Wound healing; Wound Healing - drug effects; Wounds; Indonesia; Sulawesi; antimicrobial; antioxidant; wound dressing; hydrogel films; ulvan
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S331120

Ulvan is a natural polymer and type of sulfated polysaccharides from green seaweed that could have potential as a candidate for wound dressing material based on the support of its biopolymer characteristics such as antioxidant and antimicrobial activities. In this study, we developed and prepared three different hydrogel films to explore the potency of ulvan for wound dressing application. Ulvan hydrogel films were prepared by the facile method through ionic crosslinking with boric acid and added glycerol as a plasticizer. The films were evaluated in regard to swelling degree, water vapor transmission (WVTR), Fourier transform infrared (FTIR), powder x-ray diffractometry (P-XRD), scanning electron microscopy (SEM), mechanical properties, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), antimicrobial, and antioxidant activity. The hydrogel films showed that the different concentration of ulvan in the formula affects the characteristics of the hydrogel film. The higher the concentration of ulvan in UHF, the higher the value of viscosity (201±13.45 to 689±62.23 cps for UHF5 to UHF10), swelling degree (82% to 130% for UHF5 to UHF10 at 1 h), moisture content (24%±1.94% to 18.4%±0.51 for UHF5 to UHF10), and the WVTR were obtained in the range 1856-2590g/m /24h. Meanwhile, the SEM showed porous hydrogel film. Besides, all hydrogel films can reduce hydroxyl radicals and inhibit gram-positive and negative bacteria ( , and . The swelling behavior and WVTR of these films are great and could have potential as a wound dressing biomaterial, supported by their antimicrobial and antioxidant properties.