Chronic dialysis patients with infectious spondylodiscitis have poorer outcomes than non-dialysis populations

• Published in: Therapeutics and clinical risk management Vol. 14; pp. 257 - 263
• Main Authors: Kuo, George, Sun, Wei-Chiao, Lu, Yueh-An, Chen, Chao-Yu, Kao, Huang-Kai, Lin, Jr, Yu, Chen, Yung-Chang, Hung, Cheng-Chieh, Tian, Ya-Chung, Hsu, Hsiang-Hao
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Analysis; Cardiovascular disease; Chronic kidney failure; End stage renal disease; Endocarditis; Epidemiology; Fever; Hemodialysis; Hospitals; Kidney diseases; Laboratories; Medical prognosis; Medical research; Medicine; Methicillin; Methicillin-resistant Staphylococcus aureus; Mortality; Nephrology; Original Research; Patient outcomes; Patients; Population; pyogenic spondylodiscitis; Sepsis; Staphylococcus aureus infections; Staphylococcus infections; Statistical analysis; Vertebrae; Taiwan; mortality; end stage renal disease; methicillin-resistant Staphylococcus aureus; infectious spondylodiscitis; pyogenic spondylodiscitis
• ISSN: 1176-6336; 1178-203X; 1178-203X
• DOI: 10.2147/TCRM.S153546

Infectious spondylodiscitis is a serious disease that can lead to permanent neurological deficit. Because there were only a few case reports or series featuring infectious spondylodiscitis in chronic dialysis patients, we investigated the epidemiology and outcome in the chronic dialysis patients versus general population. We retrospectively identified chronic dialysis patients admitted for infectious spondylodiscitis between January 2002 and December 2015. A total of 105 chronic dialysis patients were included, and we performed a 1:2 case-control match on propensity score in non-dialysis patients with infectious spondylodiscitis. The demographic features, clinical manifestation, infection focus, and disease outcome were recorded. A total of 302 patients entered the final analysis. Chronic dialysis patients less frequently had fever (34.3%), and in the majority, bacterial entry was through dialysis vascular access (30.5%). Methicillin-resistant (MRSA) comprised the majority of causative pathogen. The chronic dialysis group had longer hospital stay, higher in-hospital mortality, and higher 1-year mortality. The odds ratio of in-hospital mortality was 2.20 compared with the non-dialysis group. The study highlighted poorer outcome and high frequency of resistant Staphylococcus of infectious spondylodiscitis in chronic dialysis patients. Therefore, high vigilance, prompt recognition, and empiric coverage of MRSA will be important in the management of infectious spondylodiscitis in chronic dialysis patients.