Prediction of Mortality in Type 2 Diabetes From Health-Related Quality of Life (ZODIAC-4)

• Published in: Diabetes care Vol. 31; no. 5; pp. 932 - 933
• Main Authors: Kleefstra, Nanne, Landman, Gijs W.D, Houweling, Sebastiaan T, Ubink-Veltmaat, Lielith J, Logtenberg, Susan J.J, Meyboom-de Jong, Betty, Coyne, James C, Groenier, Klaas H, Bilo, Henk J.G
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2008
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Blood cholesterol; Cause of Death; Diabetes; Diabetes Mellitus, Type 2 - mortality; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - psychology; Diabetes therapy; Diabetes. Impaired glucose tolerance; Diabetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Health aspects; Health Status; Humans; Kidney Function Tests; Male; Medical sciences; Metabolic diseases; Middle Aged; Miscellaneous; Mortality; Netherlands; Netherlands - epidemiology; Proportional Hazards Models; Public health. Hygiene; Public health. Hygiene-occupational medicine; Quality of Life; Studies; Type 2 diabetes; Netherlands; Endocrinopathy; Type 2 diabetes; Human; Nutrition; Mortality; Prediction; Metabolic diseases; Predictive factor; Epidemiology; Endocrinology; Health-Related Quality of Life
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc07-2072

OBJECTIVE:--To investigate the relationship between health-related quality of life (HRQOL) and mortality in type 2 diabetes. RESEARCH DESIGN AND METHODS--In 1998, 1,143 primary care patients with type 2 diabetes participated in the Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) study. At baseline, HRQOL was assessed with the RAND-36 and, after almost 6 years, life status was retrieved. Cox proportional hazards modeling was used to investigate the association between HRQOL (continuous data) and mortality with adjustment for selected confounders (smoking, age, sex, diabetes duration, A1C, renal function, BMI, blood pressure, HDL cholesterol, and macrovascular complications). RESULTS:--The Physical Component Summary of the RAND-36 was inversely associated with mortality (hazard ratio [HR] 0.979 [95% CI 0.966-0.992]), as were two separate RAND-36 dimensions. CONCLUSIONS:--This study found that HRQOL is an independent marker of mortality and emphasizes the importance of looking beyond clinical parameters in patients with type 2 diabetes.