Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

• Published in: Scientific reports Vol. 10; no. 1; p. 21118
• Main Authors: Garcés, Maria Fernanda, Buell-Acosta, Julieth Daniela, Rodríguez-Navarro, Haiver Antonio, Pulido-Sánchez, Estefania, Rincon-Ramírez, Juan José, Moreno-Ordóñez, Diana Carolina, Franco-Vega, Roberto, Roncancio-Muñoz, Jhoan Sebastian, Burgos-Cardenas, Alvaro Javier, Lacunza, Ezequiel, Castaño, Justo P., Diéguez, Carlos, Nogueiras, Rubén, Sanchez, Elizabeth, Caminos, Jorge Eduardo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.12.2020; Nature Publishing Group
• Subjects: 631/443/319/1642; 631/443/319/2723; Adiponectin; Adipose tissue; Angiopoietin; Angiopoietin-like Proteins - blood; Blood Glucose - metabolism; Body fat; Diabetes; Diabetes mellitus; Diabetes Mellitus - blood; Dual energy X-ray absorptiometry; Fasting - blood; Glucose; Glucose tolerance; Glucose Tolerance Test; Humanities and Social Sciences; Humans; Insulin; Insulin - blood; Insulin Resistance; Leptin; Male; multidisciplinary; Obesity - blood; Obesity - complications; Science; Science (multidisciplinary); Serum levels; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-77961-8

This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m 2 ) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m 2 ) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.