Is Pathologic Complete Response the Surrogate in Primary Gastric Angiosarcoma Undergoing Doxorubicin-Based Neoadjuvant Chemotherapy? A Case Report

Angiosarcoma is a malignant tumor with low incidence. Especially in the advanced tumors, there is still a lack of knowledge of evidence-based medicine. We report a case of a 55-year-old woman with abdominal pain of 2 months of duration, which had increased in severity for 2 weeks prior to the presen...

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Published inInternational journal of general medicine Vol. 13; pp. 1515 - 1521
Main Authors Zheng, Chun-Hui, Wang, Yang, Liu, Ting-Ting, Ding, Xiao-Yan, Qu, Jian-Jun, Su, Zhi-De
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2020
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects
Abdomen
Adjuvant treatment
Angiosarcoma
Anthracyclines
Biopsy
Cancer
Case Report
Chemotherapy
Comparative analysis
CT imaging
Diagnosis
Endoscopy
gastric angiosarcoma
Lymphatic system
Medical prognosis
Metastasis
neoadjuvant chemotherapy
Pain
pathologic complete response
Patients
Sarcoma
Shoulder
Stomach
Surgery
Tumors
China
gastric angiosarcoma
neoadjuvant chemotherapy
pathologic complete response
stomach
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Summary:Angiosarcoma is a malignant tumor with low incidence. Especially in the advanced tumors, there is still a lack of knowledge of evidence-based medicine. We report a case of a 55-year-old woman with abdominal pain of 2 months of duration, which had increased in severity for 2 weeks prior to the presentation. The diagnosis is primary gastric angiosarcoma. We performed multiple disciplinary team (MDT), and doxorubicin-based neoadjuvant chemotherapy (NAC) was proposed. After two cycles of NAC, a computed tomography (CT) scan showed complete regression compared with the previous scan. An open surgery was done, and surgical specimens were confirmed as a pathological complete response (PCR) by pathological and immunohistochemical examination, but unfortunately, the patient suffered a relapse after the surgery in 3 months. Repeated endoscopic biopsy and biopsy specimen examinations can improve accuracy in diagnosis. It seems that NAC could be a candidate for advanced primary gastric angiosarcomas. But after the rapid relapse, we are wondering whether pathologic complete response is the surrogate in primary gastric angiosarcoma undergoing NAC.
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These authors contributed equally to this work
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S280375