Systemic inflammatory response markers in preeclampsia

• Published in: Journal of laboratory physicians Vol. 10; no. 3; pp. 316 - 319
• Main Authors: Çintesun, Ersin, Çintesun, Feyza Nur Incesu, Ezveci, Huriye, Akyürek, Fikret, Çelik, Çetin
• Format: Journal Article
• Language: English
• Published: A-12, Second Floor, Sector -2, NOIDA -201301, India Thieme Medical and Scientific Publishers Private Ltd 01.07.2018; Wolters Kluwer India Pvt. Ltd; Medknow Publications and Media Pvt. Ltd; Thieme Medical Publishers Inc; Medknow Publications & Media Pvt Ltd; Thieme Medical and Scientific Publishers Pvt. Ltd
• Subjects: Blood platelets; Blood pressure; Blood tests; Cardiovascular disease; Cytokines; Edema; Gynecology; Hypertension; inflammatory; lymphocyte; Lymphocytes; neutrophil; Neutrophils; Obstetrics; Original; Original Article; Patients; platelet; Preeclampsia; Pregnant women; Studies; Systemic diseases; Women's health; Womens health; Inflammatory; platelet; preeclampsia; neutrophil; lymphocyte
• ISSN: 0974-2727; 0974-7826
• DOI: 10.4103/JLP.JLP_144_17

ABSTRACT PURPOSE: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), red cell distribution width (RDW), mean platelet volume (MPV), and plateletcrit (PCT) are known as systemic inflammatory response markers. In this study, we aimed to evaluate changes in NLR, PLR, PDW, RDW, MPV, and PCT in preeclampsia (PE) and their use in predicting its severity. MATERIALS AND METHODS: This is a retrospective case–control study. The study comprised 64 control group (healthy pregnant females), 51 females with mild PE, and 13 with severe PE. These three groups were compared with demographic data and inflammation markers. RESULTS: There were no statistically significant differences between healthy pregnant females and preeclaptic females in terms of median age, hemoglobin, lymphocyte, neutrophil, platelet, NLR, PLR, PDV, RDW, MPV, PCT ( P > 0.05). The control group has a higher number of gravity and parity than the PE group ( P < 0.001). MPV value is a lower PE group than the control group ( P < 0.001). Both gravity and parity were significantly higher in the patients with mild PE than in the control group ( P < 0.001). MPV value was statistically higher in the control group compared both mild and severe PE ( P < 0.001), however, no statistical difference between mild and severe PE ( P = 0.305). CONCLUSIONS: MPV may be clinically useful markers in the prediction of PE. Further, prospective multicenter studies are needed to reveal the association between these markers and PE.