Outer membrane vesicles for vaccination and targeted drug delivery

Extracellular vesicles (EVs) are cell membrane-derived compartments that spontaneously secrete from a wide range of cells and tissues. EVs have shown to be the carriers in delivering drugs and small interfering RNA. Among EVs, bacterial outer membrane vesicles (OMVs) recently have gained the interes...

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Bibliographic Details
Published inWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Vol. 11; no. 2; p. e1523
Main Authors Wang, Sihan, Gao, Jin, Wang, Zhenjia
Format Journal Article
LanguageEnglish
Published United States 01.03.2019
Subjects
Animals
Bacteria - pathogenicity
Bioengineering
Cell Membrane - metabolism
Drug Delivery Systems
Extracellular Vesicles - metabolism
Humans
Vaccination
OMVs-based drug delivery
secretion pathway
vaccines
OMVs
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Summary:Extracellular vesicles (EVs) are cell membrane-derived compartments that spontaneously secrete from a wide range of cells and tissues. EVs have shown to be the carriers in delivering drugs and small interfering RNA. Among EVs, bacterial outer membrane vesicles (OMVs) recently have gained the interest in vaccine development and targeted drug delivery. In this review, we summarize the current discoveries of OMVs and their functions. In particular, we focus on the biogenesis of OMVs and their functions in bacterial virulence and pathogenesis. Furthermore, we discuss the applications of OMVs in vaccination and targeted drug delivery. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Lipid-Based Structures.
ISSN:1939-0041
DOI:10.1002/wnan.1523