Resveratrol‐loaded nanomedicines for cancer applications
Background Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant properties. However, its poor water solubility, low...
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Published in | Cancer reports Vol. 4; no. 3; pp. e1353 - n/a |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
John Wiley & Sons, Inc
01.06.2021
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half‐life limit its clinical utility.
Recent findings
Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues. This review focuses on the physicochemical properties of resveratrol, the therapeutic potential of resveratrol nano‐formulations, and the anticancer activity of resveratrol encapsulated nanoparticles on various malignancies such as skin, breast, prostate, colon, liver, ovarian, and lung cancers (focusing on both in vitro and in vivo studies).
Conclusions
Nanotechnology approaches have been extensively utilized to achieve higher solubility, improved oral bioavailability, enhanced stability, and controlled release of resveratrol. The resveratrol nanoparticles have markedly enhanced its anticancer activity both in vitro and in vivo, thus considering it as a potential strategy to fight various cancers. |
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Bibliography: | Funding information Auburn University ‐ Intramural Grant Program; Auburn University Presidential Initiative in Interdisciplinary Research (PAIR) grants; Auburn University Research Initiative in Cancer (AURIC) Funding information Auburn University ‐ Intramural Grant Program; Auburn University Presidential Initiative in Interdisciplinary Research (PAIR) grants; Auburn University Research Initiative in Cancer (AURIC) |
ISSN: | 2573-8348 2573-8348 |
DOI: | 10.1002/cnr2.1353 |