器官芯片及其应用

微流控芯片是细胞体外培养的重要平台,基于该平台所发展的器官芯片技术更因其能够模拟人体器官的复杂结构及功能而受到重视。本文从不同器官的角度介绍了近年来器官芯片技术在构建人体生理学模型、药物研发及毒理学研究中的应用,并对器官芯片技术的发展前景进行了展望。...

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Bibliographic Details
Published in分析化学 Vol. 44; no. 4; pp. 533 - 541
Main Author 孙威 陈雨晴 罗国安 张敏 章弘扬 王月荣 胡坪
Format Journal Article
LanguageChinese
Published 上海市功能性材料化学重点实验室,华东理工大学化学与分子工程学院,上海200237%清华大学化学系,北京10084 2016
华东理工大学药学院上海市新药设计重点实验室,上海200237%华东理工大学药学院上海市新药设计重点实验室,上海,200237
Subjects
人体器官
器官芯片
微流控芯片
细胞
综述
微流控芯片
器官芯片
细胞
人体器官
Microfluidic chip
综述
Review
Organs-on-chips
Human organ
Cell
Online AccessGet full text
ISSN0253-3820
DOI10.11895/j.issn.0253-3820.150857

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Summary:微流控芯片是细胞体外培养的重要平台,基于该平台所发展的器官芯片技术更因其能够模拟人体器官的复杂结构及功能而受到重视。本文从不同器官的角度介绍了近年来器官芯片技术在构建人体生理学模型、药物研发及毒理学研究中的应用,并对器官芯片技术的发展前景进行了展望。
Bibliography:Microfluidic chip; Organs-on-chips; Cell; Human organ; Review
SUN Wei;CHEN Yu-Qing;LUO Guo-An;ZHANG Min;ZHANG Hong-Yang;WANG Yue-Rong;HU Ping; 1 （ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China） 2（Department of Chemistry, Tsinghua University, Beijing 10054, China） 3（ Shanghai Key Laboratory of New Drug Design ＆ Modern Engineering Center for TCM, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China）
22-1125/O6
Microfluidic chips are significant platforms of cell culture in vitro. Microfluidic chip-based organson-chips technology has received attention because it can mimic the complex structures and functions of human organs. In this review,the recent advances of organs-on-chips technology in different organs are reported including the build of human physiological models, drug discovery and toxicology research. And the development of this technolo
ISSN:0253-3820
DOI:10.11895/j.issn.0253-3820.150857