Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus

• Published in: Neuroscience Vol. 284; pp. 601 - 610
• Main Authors: Trandafir, C.C, Pouliot, W.A, Dudek, F.E, Ekstrand, J.J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 22.01.2015
• Subjects: Animals; Anticonvulsants - administration & dosage; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - administration & dosage; cyclooxygenase-2 (COX-2); Diazepam - administration & dosage; Disease Models, Animal; Drug Therapy, Combination - methods; Electrodes, Implanted; Electroencephalography; Hippocampus - drug effects; Hippocampus - pathology; Hippocampus - physiopathology; inflammation; Lithium Compounds; Male; Neurology; Neurons - drug effects; Neurons - pathology; Neurons - physiology; neuroprotection; Neuroprotective Agents - administration & dosage; Nitrobenzenes - administration & dosage; Pilocarpine; Rats, Sprague-Dawley; Status Epilepticus - drug therapy; Status Epilepticus - pathology; Status Epilepticus - physiopathology; Sulfonamides - administration & dosage; status epilepticus; cyclooxygenase-2 (COX-2); SE; COX-2; inflammation; EEG; neuroprotection; cyclooxygenase-2; PGE 2; prostaglandin E 2; electroencephalogram; PGE2
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.10.021

Highlights • NS-398 is neuroprotective in the hippocampus after pilocarpine-induced status epilepticus. • Co-administration with diazepam enhances neuroprotective effect of NS-398. • NS-398 and diazepam did not affect duration or severity of status epilepticus.