Local N-methyl- d -aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats

• Published in: Neuroscience Vol. 288; pp. 73 - 85
• Main Authors: Locklear, M.N, Bhamidipaty, S, Kritzer, M.F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 12.03.2015
• Subjects: 2-Amino-5-phosphonovalerate - pharmacology; androgen; Animals; Barnes maze; Cognition Disorders - drug therapy; Cognition Disorders - physiopathology; Estradiol - administration & dosage; estrogen; Excitatory Amino Acid Antagonists - pharmacology; executive function; Hormones - administration & dosage; Male; Maze Learning - drug effects; Maze Learning - physiology; Neurology; Orchiectomy; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiopathology; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; schizophrenia; Testosterone Propionate - administration & dosage; working memory; estrogen; saline; D(−)-2-amino-5-phosphonopentanoic acid; E; N-methyl- d-aspartate; prefrontal cortex; (R)-CPP; schizophrenia; PFC; testosterone propionate; GLU; analysis of variance; ANOVA; working memory; APV, apv; NMDA; GDX; BSM; glutamate; estradiol; androgen; gonadectomy; 3-[(R)-2-carboxypiperazine-4-yl]-propyl-1-phosphoric acid; bulbospongiosus muscle; control; N-methyl- d-aspartate receptor; s; CTRL; NMDAR; MK801; Barnes maze; TP; DA; dopamine; dizolcilpine; executive function
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.12.032

Highlights • NMDA receptor block in the prefrontal cortex impairs Barnes maze performance in male rats. • NMDA receptor block in the prefrontal cortex improved cognition in gonadectomized rats. • Estrogen and androgen modulate cognition through NMDA receptors in the prefrontal cortex.