Wireless multilateral devices for optogenetic studies of individual and social behaviors

Advanced technologies for controlled delivery of light to targeted locations in biological tissues are essential to neuroscience research that applies optogenetics in animal models. Fully implantable, miniaturized devices with wireless control and power-harvesting strategies offer an appealing set o...

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Bibliographic Details
Published inNature neuroscience Vol. 24; no. 7; pp. 1035 - 1045
Main Authors Yang, Yiyuan, Wu, Mingzheng, Vázquez-Guardado, Abraham, Wegener, Amy J., Grajales-Reyes, Jose G., Deng, Yujun, Wang, Taoyi, Avila, Raudel, Moreno, Justin A., Minkowicz, Samuel, Dumrongprechachan, Vasin, Lee, Jungyup, Zhang, Shuangyang, Legaria, Alex A., Ma, Yuhang, Mehta, Sunita, Franklin, Daniel, Hartman, Layne, Bai, Wubin, Han, Mengdi, Zhao, Hangbo, Lu, Wei, Yu, Yongjoon, Sheng, Xing, Banks, Anthony, Yu, Xinge, Donaldson, Zoe R., Gereau, Robert W., Good, Cameron H., Xie, Zhaoqian, Huang, Yonggang, Kozorovitskiy, Yevgenia, Rogers, John A.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.07.2021
Nature Publishing Group
Subjects
13/1
13/51
42/35
631/1647/2253
631/378
64/110
9/74
Animal experimentation
Animal Genetics and Genomics
Animal models
Animals
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain research
Fiber optics
Genetics
Human acts
Human behavior
Information processing
Light sources
Methods
Mice
Nervous system
Neural circuitry
Neurobiology
Neurosciences
Optics
Optoelectronics
Optogenetics - instrumentation
Prefrontal cortex
Real-time programming
Social Behavior
Social factors
technical-report
Thermal properties
Thermodynamic properties
Tissues
Wireless Technology - instrumentation
United States
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Summary:Advanced technologies for controlled delivery of light to targeted locations in biological tissues are essential to neuroscience research that applies optogenetics in animal models. Fully implantable, miniaturized devices with wireless control and power-harvesting strategies offer an appealing set of attributes in this context, particularly for studies that are incompatible with conventional fiber-optic approaches or battery-powered head stages. Limited programmable control and narrow options in illumination profiles constrain the use of existing devices. The results reported here overcome these drawbacks via two platforms, both with real-time user programmability over multiple independent light sources, in head-mounted and back-mounted designs. Engineering studies of the optoelectronic and thermal properties of these systems define their capabilities and key design considerations. Neuroscience applications demonstrate that induction of interbrain neuronal synchrony in the medial prefrontal cortex shapes social interaction within groups of mice, highlighting the power of real-time subject-specific programmability of the wireless optogenetic platforms introduced here. The authors introduce advanced technology for controlled wireless light delivery in optogenetics applications with real-time user programming capacity. The utility of the platform is highlighted by induction of neural synchrony to modify social behavior in mice.
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Y. Yang, Z.X., M.W., A.V.-G., R.W.G., C.H.G., Z.R.D., Y.H., Y.K., and J.A.R. contributed ideas and designed research. Y. Yang, Z.X., C.H.G. and J.A.R. proposed the platform design. Z.X., Y.D., R.A., S.Z. and Y.H. conducted structural optimization and performed electromagnetic, optical and thermal modeling and analysis. M.W., S. Minkowicz, V.D., Z.R.D. and Y.K. designed, carried out, and analyzed optogenetic studies and body motion tests. A.V.-G., and Y. Yang established the electronic system. A.J.W., J.G.G., M.W., J.A.M. R.W.G., and C.H.G. developed implantation processes. A.J.W., J.G.G., J.A.M. and C.H.G. conducted mobility studies. Y. Yang, M.W., A.V.-G., Z.X., A.J.W., J.G.G., Y.D., T.W., R.A., J.A.M., S. Minkowicz, V.D., J.L., S.Z., A.A.L., Y.M., S. Mehta, D.F., L.H., W.B., M.H., H.Z., W.L., Y. Yu, X.S., A.B., X.Y., and C.H.G. performed experiments. Y. Yang, M.W., Z.X., A.V.-G., A.J.W., J.G.G., Z.R.D., Y.K. and C.H.G. analyzed data. Y. Yang, Z.X., M.W., A.V.-G., A.J.W., C.H.G., Z.R.D., Y.H., Y.K., and J.A.R. wrote the paper with input from other authors.
Author Contributions
These authors contributed equally in this work: Yiyuan Yang, Mingzheng Wu, Abraham Vázquez-Guardado.
ISSN:1097-6256
1546-1726
1546-1726
DOI:10.1038/s41593-021-00849-x