GABAergic inhibition shapes SAM responses in rat auditory thalamus

• Published in: Neuroscience Vol. 299; pp. 146 - 155
• Main Authors: Cai, R, Caspary, D.M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 23.07.2015
• Subjects: Acoustic Stimulation; Animals; auditory thalamus; GABA-A Receptor Antagonists - pharmacology; gamma-Aminobutyric Acid - metabolism; Geniculate Bodies - drug effects; Geniculate Bodies - physiology; inhibition–excitation balance; Male; Neural Inhibition; Neurology; Neurons - drug effects; Neurons - physiology; Pyridazines - pharmacology; Rats; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; SAM response; Sound; Synaptic Transmission - drug effects; Valine - analogs & derivatives; Valine - pharmacology; vector strength; GABA A receptor; SAM response; HP; medial geniculate body; dorsal/ventral medial geniculate body; N-methyl- d-aspartic acid; sinusoidal amplitude modulation; d/vMGB; multichannel acquisition processor; BBN; TRN; IC; modulation transfer function; bandpass; GABA AR; gabazine; broadband noise; rate/temporal best modulation frequency; AC; modulation frequency; carrier frequency; highpass; primary auditory cortex; r/tBMF; characteristic frequency; γ-aminobutyric acid; GABA; thalamic reticular nucleus; fc; MAP; VS; SAM; auditory thalamus; inhibition–excitation balance; fm; rWMF; best modulation frequency; KAc; BP; SNR; rate worst modulation frequency; NMDA; inferior colliculus; BMF; r/tMTF; GBZ; CF; AP5; MGB; (2R)-amino-5-phosphonovaleric acid; potassium acetate; rate/temporal modulation transfer function; signal-to-noise ratio; MTF; GABAAR
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.04.062

Highlights • Medial geniculate body shows emergent properties in its coding of modulated stimuli. • A delicate balance of tonic GABA and NMDA signaling regulates coding of modulated signals. • Coding of higher modulation frequencies is uniquely shaped by GABA.