Tissue Chips in Space: Modeling Human Diseases in Microgravity
Purpose Microphysiological systems (MPS), also known as “organs-on-chips” or “tissue chips,” leverage recent advances in cell biology, tissue engineering, and microfabrication to create in vitro models of human organs and tissues. These systems offer promising solutions for modeling human physiology...
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Published in | Pharmaceutical research Vol. 37; no. 1; pp. 8 - 6 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.01.2020
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
Microphysiological systems (MPS), also known as “organs-on-chips” or “tissue chips,” leverage recent advances in cell biology, tissue engineering, and microfabrication to create
in vitro
models of human organs and tissues. These systems offer promising solutions for modeling human physiology and disease
in vitro
and have multiple applications in areas where traditional cell culture and animal models fall short. Recently, the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) and the International Space Station (ISS) U.S. National Laboratory have coordinated efforts to facilitate the launch and use of these MPS platforms onboard the ISS. Here, we provide an introduction to the NIH Tissue Chips in Space initiative and an overview of the coordinated efforts between NIH and the ISS National Laboratory. We also highlight the current progress in addressing the scientific and technical challenges encountered in the development of these ambitious projects. Finally, we describe the potential impact of the Tissue Chips in Space program for the MPS field as well as the wider biomedical and health research communities. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0724-8741 1573-904X |
DOI: | 10.1007/s11095-019-2742-0 |