Current trends and challenges of fecal microbiota transplantation—An easy method that works for all?

• Published in: Biomedicines Vol. 10(11); no. 11; pp. 1 - 19
• Main Authors: Almeida, Cátia, Oliveira, Rita, BAYLINA MACHADO, PILAR, Fernandes, Rúben, Teixeira, Fábio G., Barata, Pedro
• Format: Journal Article
• Language: English
• Published: Basel MDPI 28.10.2022; MDPI AG
• Subjects: Bacteria; Cancer; Cardiometabolic disorders; Colonoscopy; Diarrhea; Digestive system; Fecal microbiota transplantation; Fecal microflora; Feces; Gastrointestinal disorders; Gastrointestinal tract; Gender; Gut microbiota; Health aspects; Hypotheses; Immune system; Infectious diseases; Intestinal microflora; Males; Metabolic disorders; Metabolism; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Neurological disorders; Review; Side effects; Transplantation; Portugal
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines10112742

The gut microbiota refers to bacteria lodges in the gastrointestinal tract (GIT) that interact through various complex mechanisms. The disturbance of this ecosystem has been correlated with several diseases, such as neurologic, respiratory, cardiovascular, and metabolic diseases and cancer. Therefore, the modulation of the gut microbiota has emerged as a potential therapeutic tool; of the various forms of gut microbiota modulation, fecal microbiota transplantation (FMT) is the most approached. This recent technique involves introducing fecal material from a healthy donor into the patient’s gastrointestinal tract, aiming to restore the gut microbiota and lead to the resolution of symptoms. This procedure implies a careful donor choice, fine collection and handling of fecal material, and a balanced preparation of the recipient and consequent administration of the prepared content. Although FMT is considered a biological therapy with promising effects, side effects such as diarrhea and abdominal pain have also been claimed, making this a significant challenge in the application of FMT. Bearing this in mind, the present review aims to summarize the recent advances in understanding FMT mechanisms, their impact across different pathological conditions, and the associated side effects, emphasizing the most recent published data.