Host-microbe interactions in the gut of Drosophila melanogaster

Many insect species subsist on decaying and contaminated matter and are thus exposed to large quantities of microorganisms. To control beneficial commensals and combat infectious pathogens, insects must be armed with efficient systems for microbial recognition, signaling pathways, and effector molec...

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Published inFrontiers in physiology Vol. 4; p. 375
Main Authors Kuraishi, Takayuki, Hori, Aki, Kurata, Shoichiro
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2013
Subjects
Antimicrobial peptide
Drosophila
gut flora
innate immunity
peritrophic matrix
Physiology
Reactive Oxygen Species
peritrophic matrix
intestinal stem cell
innate immunity
Drosophila
reactive oxygen species
antimicrobial peptide
gut flora
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Summary:Many insect species subsist on decaying and contaminated matter and are thus exposed to large quantities of microorganisms. To control beneficial commensals and combat infectious pathogens, insects must be armed with efficient systems for microbial recognition, signaling pathways, and effector molecules. The molecular mechanisms regulating these host-microbe interactions in insects have been largely clarified in Drosophila melanogaster with its powerful genetic and genomic tools. Here we review recent advances in this field, focusing mainly on the relationships between microbes and epithelial cells in the intestinal tract where the host exposure to the external environment is most frequent.
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Reviewed by: Sara Cherry, University of Pennsylvania, USA; Shun-ichiro Kawabata, Kyushu University, Japan
Edited by: Shinji Nagata, University of Tokyo, Japan
This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology.
These authors have contributed equally to this work.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2013.00375