Visual and histological evaluation of the effects of trafermin in a dog oronasal fistula model

• Published in: Journal of Veterinary Medical Science Vol. 84; no. 1; pp. 64 - 68
• Main Authors: WATANABE, Kazuhiro, TAHARA, Syun, KOYAMA, Hiroyuki, SHIMIZU, Mamu, KAWABE, Mifumi, MIYAWAKI, Shingo
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2022; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; Canine teeth; dog; Dog Diseases; Dogs; Fibroblast Growth Factors; Fistula; Fistula - veterinary; Fistulae; Nose Diseases - veterinary; Oral Fistula - veterinary; oronasal fistula; Peptide Fragments; periodontal regeneration; recombinant human basic fibroblast growth factor; Surgery; trafermin; periodontal regeneration; trafermin; dog; oronasal fistula; recombinant human basic fibroblast growth factor
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.21-0393

The standard procedure to treat oronasal fistula in dogs requires tooth extraction to close the fistula; hence, the subject would lose its tooth. In this study, trafermin was applied to four dog models with oronasal fistula to investigate the periodontal tissue regenerative effects of trafermin in the treatment without tooth extraction. A fistula was created along the palatal side of each upper canine tooth. One of the fistulae was filled with trafermin, whereas that on the contralateral side was left unfilled as a control. The results showed a significant decrease in the non-calcified periodontal tissue volume on the trafermin side after the fourth week. In addition, oronasal fistula closure was visually and histologically confirmed at the eighth week on the trafermin side of all four models.