Improving human health through understanding the complex structure of glucose polymers

• Published in: Analytical and bioanalytical chemistry Vol. 405; no. 28; pp. 8969 - 8980
• Main Authors: Gilbert, Robert G., Wu, Alex C., Sullivan, Mitchell A., Sumarriva, Gonzalo E., Ersch, Natascha, Hasjim, Jovin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2013; Springer; Springer Nature B.V
• Subjects: amylose; Analytical Chemistry; Biochemistry; Biosynthesis; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Colorectal cancer; colorectal neoplasms; Complications and side effects; Diabetes; digestibility; digestion; disease prevention; drugs; Food Science; Food, Organic - analysis; foods; Fractionation; Glucose; Glucose - analysis; glycogen; Glycogen - chemistry; Glycogen - metabolism; Glycogens; Health; Homeostasis; Human; human health; Humans; Hyperglycemia; Insulin; interpersonal relationships; Laboratory animals; Laboratory Medicine; Light scattering; Liver; Mathematical analysis; Mathematical models; metabolic diseases; Metabolic disorders; Molecular weight; Monitoring/Environmental Analysis; Nutrition; Nutritive value; patients; Physiological aspects; Polymers; Prevention; Review; Risk factors; Separation and Characterization of Natural and Synthetic Macromolecules; Starch; Starch - chemistry; Starch - metabolism; Starches; China; Separations/instrumentation; Field-flow fractionation; Polymers; Health; Separations/theory; Foods/beverages
• ISSN: 1618-2642; 1618-2650; 1618-2650
• DOI: 10.1007/s00216-013-7129-1

Two highly branched glucose polymers with similar structures—starch and glycogen—have important relations to human health. Slowly digestible and resistant starches have desirable health benefits, including the prevention and alleviation of metabolic diseases and prevention of colon cancer. Glycogen is important in regulating the use of glucose in the body, and diabetic subjects have an anomaly in their glycogen structure compared with that in healthy subjects. This paper reviews the biosynthesis–structure–property relations of these polymers, showing that polymer characterization produces knowledge which can be useful in producing healthier foods and new drug targets aimed at improving glucose storage in diabetic patients. Examples include mathematical modeling to design starch with better nutritional values, the effects of amylose fine structures on starch digestibility, the structure of slowly digested starch collected from in vitro and in vivo digestion, and the mechanism of the formation of glycogen α particles from β particles in healthy subjects. A new method to overcome a current problem in the structural characterization of these polymers using field-flow fractionation is also given, through a technique to calibrate evaporative light scattering detection with starch. Figure ᅟ