Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus

• Published in: The New England journal of medicine Vol. 361; no. 20; pp. 1945 - 1952
• Main Authors: Hancock, Kathy, Veguilla, Vic, Lu, Xiuhua, Zhong, Weimin, Butler, Eboneé N, Sun, Hong, Liu, Feng, Dong, Libo, DeVos, Joshua R, Gargiullo, Paul M, Brammer, T. Lynnette, Cox, Nancy J, Tumpey, Terrence M, Katz, Jacqueline M
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 12.11.2009
• Subjects: Adult; Age Distribution; Aged; Aged, 80 and over; Antibodies, Viral - blood; Biological and medical sciences; Confidence intervals; Cross Reactions; Female; General aspects; Human viral diseases; Humans; Infectious diseases; Influenza A Virus, H1N1 Subtype - immunology; Influenza Vaccines - immunology; Influenza, Human - immunology; Male; Medical sciences; Middle Aged; Miscellaneous; Neutralization Tests; Public health; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression analysis; Swine flu; Vaccines; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Viruses; Young Adult; United States > US; Immune response; Antibody; Orthomyxoviridae; Influenzavirus; Infection; Virus; 2009; Medicine; Viral disease; Influenza; Cross reaction; Humoral immunity; Public health
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa0906453

Using stored serum samples from blood donors and subjects in previous influenza vaccine trials, CDC investigators found that vaccination with the routine trivalent seasonal influenza vaccine induced little immunity against the current pandemic H1N1 virus and that 34% of subjects born before 1950 had some immunity to this pandemic virus. CDC investigators found that vaccination with the routine trivalent seasonal influenza vaccine induced little immunity against the current pandemic H1N1 virus and that 34% of subjects born before 1950 had some immunity to this pandemic virus. On June 11, 2009, the World Health Organization declared that an influenza pandemic was under way. The 2009 pandemic H1N1 virus (2009 H1N1) has a unique combination of genes from both North American and Eurasian swine lineages that has not been identified previously in either swine or human populations. 1 , 2 The hemagglutinin gene of 2009 H1N1 belongs to the classical swine lineage, which was first introduced into swine populations around 1918 and shares antigenic similarity with triple reassortant swine influenza viruses that have circulated in pigs in the United States for more than a decade; these strains have been associated . . .