Estimating repetitive spatiotemporal patterns from many subjects’ resting-state fMRIs

• Published in: NeuroImage (Orlando, Fla.) Vol. 203; p. 116182
• Main Authors: Takeda, Yusuke, Itahashi, Takashi, Sato, Masa-aki, Yamashita, Okito
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2019; Elsevier Limited
• Subjects: Autism; Big data; Brain mapping; Brain research; Data exchange; Electroencephalography; fMRI; Functional magnetic resonance imaging; Medical imaging; Memory; Neuroimaging; R&D; Research & development; Resting state; Retina; Sensorimotor system; Sensory integration; Spatiotemporal pattern; The autism brain imaging data exchange (ABIDE); fMRI; Big data; Resting state; Spatiotemporal pattern; The autism brain imaging data exchange (ABIDE)
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2019.116182

Recently, we proposed a method to estimate repetitive spatiotemporal patterns from resting-state brain activity data (SpatioTemporal Pattern estimation, STeP) (Takeda et al., 2016). From such resting-state data as functional MRI (fMRI), STeP can estimate several spatiotemporal patterns and their onsets even if they are overlapping. Nowadays, a growing number of resting-state data are publicly available from such databases as the Autism Brain Imaging Data Exchange (ABIDE), which promote a better understanding of resting-state brain activities. In this study, we extend STeP to make it applicable to such big databases, thus proposing the method we call BigSTeP. From many subjects’ resting-state data, BigSTeP estimates spatiotemporal patterns that are common across subjects (common spatiotemporal patterns) as well as the corresponding spatiotemporal patterns in each subject (subject-specific spatiotemporal patterns). After verifying the performance of BigSTeP by simulation tests, we applied it to over 1,000 subjects’ resting-state fMRIs (rsfMRIs) obtained from ABIDE I. This revealed two common spatiotemporal patterns and the corresponding subject-specific spatiotemporal patterns. The common spatiotemporal patterns included spatial patterns resembling the default mode (DMN), sensorimotor, auditory, and visual networks, suggesting that these networks are time-locked with each other. We compared the subject-specific spatiotemporal patterns between autism spectrum disorder (ASD) and typically developed (TD) groups. As a result, significant differences were concentrated at a specific time in a pattern, when the DMN exhibited large positive activity. This suggests that the differences are context-dependent, that is, the differences in fMRI activities between ASDs and TDs do not always occur during the resting state but tend to occur when the DMN exhibits large positive activity. All of these results demonstrate the usefulness of BigSTeP in extracting inspiring hypotheses from big databases in a data-driven way. •We propose a method to estimate spatiotemporal patterns from resting-state data.•It can be applied to big databases, such as ABIDE and HCP.•It provides robust knowledge on spatiotemporal brain dynamics in the resting state.