QuickNAT: A fully convolutional network for quick and accurate segmentation of neuroanatomy

• Published in: NeuroImage (Orlando, Fla.) Vol. 186; pp. 713 - 727
• Main Authors: Guha Roy, Abhijit, Conjeti, Sailesh, Navab, Nassir, Wachinger, Christian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2019; Elsevier Limited
• Subjects: Accuracy; Algorithms; Anatomy; Annotations; Architecture; Brain architecture; Brain segmentation; Data processing; Datasets; Decision making; Deep learning; Fully convolutional neural networks; Image processing; Magnetic resonance imaging; Morphology; MRI T1 scans; Neural networks; Neuroimaging; NMR; Nuclear magnetic resonance; Segmentation; Deep learning; Brain segmentation; Fully convolutional neural networks; MRI T1 scans
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2018.11.042

Whole brain segmentation from structural magnetic resonance imaging (MRI) is a prerequisite for most morphological analyses, but is computationally intense and can therefore delay the availability of image markers after scan acquisition. We introduce QuickNAT, a fully convolutional, densely connected neural network that segments a MRI brain scan in 20 s. To enable training of the complex network with millions of learnable parameters using limited annotated data, we propose to first pre-train on auxiliary labels created from existing segmentation software. Subsequently, the pre-trained model is fine-tuned on manual labels to rectify errors in auxiliary labels. With this learning strategy, we are able to use large neuroimaging repositories without manual annotations for training. In an extensive set of evaluations on eight datasets that cover a wide age range, pathology, and different scanners, we demonstrate that QuickNAT achieves superior segmentation accuracy and reliability in comparison to state-of-the-art methods, while being orders of magnitude faster. The speed up facilitates processing of large data repositories and supports translation of imaging biomarkers by making them available within seconds for fast clinical decision making. [Display omitted] •Introduces a deep learning based whole brain segmentation tool called QuickNAT, processing each 3D MRI T1 brain scans in 20 secs.•The high segmentation accuracy of QuickNAT was evaluated on 5 different benchmark datasets, containing a wide age range, subjects with different pathologies (AD, MCI and CN), and different scanners (1.5T and 3.0T).•QuickNAT can be effectively used for longitudinal studies as it performs well in test-retest and multi-center experiments.