DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus

The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP)...

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Published inVirology journal Vol. 20; no. 1; pp. 1 - 250
Main Authors Wu, Xinna, Zhou, Xuqiang, Wang, Sanying, Mao, Genxiang
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 01.11.2023
BioMed Central
BMC
Subjects
Apoptosis
Care and treatment
Causes of
Cell cycle
Cell division
Cellular senescence
Cyclin-dependent kinases
Cytokines
Cytomegalovirus
Cytomegaloviruses
DNA
DNA damage
DNA repair
Health aspects
Herpes viruses
Human cytomegalovirus
Inflammation
Kinases
Patient outcomes
Phenotypes
Proteins
Review
Senescence
Senescence-associated secretory phenotype
Viral infections
Canada
China
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Summary:The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory cytokines. Human cytomegalovirus (HCMV) is a ubiquitous pathogen that plays an important role in the senescence process. It has been established that DDR is necessary for HCMV to replicate effectively. This paper reviews the relationship between DDR, cellular senescence, and HCMV, providing new sights for virus-induced senescence (VIS).
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-023-02203-y