The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

As of late, polyphenols have increasingly interested the scientific community due to their proposed health benefits. Much of this attention has focused on their bioavailability. Polyphenol-gut microbiota interactions should be considered to understand their biological functions. The dichotomy betwee...

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Bibliographic Details
Published inNutrients Vol. 8; no. 2; p. 78
Main Authors Ozdal, Tugba, Sela, David A, Xiao, Jianbo, Boyacioglu, Dilek, Chen, Fang, Capanoglu, Esra
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.02.2016
MDPI
Subjects
Bioavailability
Biological Availability
Biotransformation
flavonoids
Gastrointestinal Microbiome - drug effects
gut microbiota
Health
Humans
In vivo methods and tests
interactions
Intestinal microflora
Metabolites
microbial metabolism
Microbiota
phenolics
Polyphenols
Polyphenols - metabolism
Polyphenols - pharmacology
Review
polyphenols
microbial metabolism
bioavailability
health
flavonoids
gut microbiota
interactions
phenolics
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Summary:As of late, polyphenols have increasingly interested the scientific community due to their proposed health benefits. Much of this attention has focused on their bioavailability. Polyphenol-gut microbiota interactions should be considered to understand their biological functions. The dichotomy between the biotransformation of polyphenols into their metabolites by gut microbiota and the modulation of gut microbiota composition by polyphenols contributes to positive health outcomes. Although there are many studies on the in vivo bioavailability of polyphenols, the mutual relationship between polyphenols and gut microbiota is not fully understood. This review focuses on the biotransformation of polyphenols by gut microbiota, modulation of gut microbiota by polyphenols, and the effects of these two-way mutual interactions on polyphenol bioavailability, and ultimately, human health.
Bibliography:These authors contributed equally to this work.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu8020078