External globus pallidus stimulation modulates brain connectivity in Huntington's disease

• Published in: Journal of cerebral blood flow and metabolism Vol. 31; no. 1; pp. 41 - 46
• Main Authors: Ligot, Noémie, Krystkowiak, Pierre, Simonin, Clémence, Goldman, Serge, Peigneux, Philippe, Van Naemen, John, Monclus, Michel, Lacroix, Simon Frédéric, Devos, David, Dujardin, Kathy, Delmaire, Christine, Bardinet, Eric, Delval, Arnaud, Delliaux, Marie, Defebvre, Luc, Yelnik, Jerome, Blond, Serge, Destée, Alain, De Tiège, Xavier
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2011; Nature Publishing Group; Sage Publications Ltd
• Subjects: Adult; Basal Ganglia - physiology; Biological and medical sciences; Brief Communication; Cerebral Cortex - physiology; Cerebrovascular Circulation - physiology; Computer Science; Deep Brain Stimulation; Female; Globus Pallidus - physiology; Humans; Huntington Disease - diagnostic imaging; Huntington Disease - therapy; Image Processing, Computer-Assisted; Investigative techniques, diagnostic techniques (general aspects); Male; Medical Imaging; Medical sciences; Middle Aged; Nerve Net - physiology; Nervous system; Neural Pathways - physiology; Neurology; Neurons - physiology; Oxygen Radioisotopes; Positron-Emission Tomography; Thalamus - physiology; Ultrasonic investigative techniques; Vascular diseases and vascular malformations of the nervous system; default-mode network; basal ganglia; Huntington's disease; positron emission tomography; deep brain stimulation; Nervous system diseases; Huntington disease; Basal ganglion; Genetic disease; Encephalon; Cerebral disorder; Central nervous system disease; Degenerative disease; Positron emission tomography; Cerebrovascular disease; Extrapyramidal syndrome; Emission tomography
• ISSN: 0271-678X; 1559-7016
• DOI: 10.1038/jcbfm.2010.186

Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.