Analysis of human hippocampal volumetry in relation to pattern separation ability in healthy young subjects

• Published in: Brain and behavior Vol. 10; no. 12; pp. e01878 - n/a
• Main Authors: Usugi, Ryoichi, Nishimura, Masahiko, Ishiuchi, Shogo
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2020; John Wiley and Sons Inc; Wiley
• Subjects: Alzheimer's disease; Automation; Brain research; dentate gyrus; hippocampal subfields; hippocampal‐amygdaloid transition area HATA; Hypotheses; Memory; Neurogenesis; Original Research; pattern separation; Software; Volumetric analysis; volumetric MRI; United States > US; dentate gyrus; pattern separation; hippocampal subfields; volumetric MRI; hippocampal-amygdaloid transition area HATA
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1878

Introduction Hippocampal dentate gyrus related to pattern separation has attracted attention as an area for neurogenesis. However, the associations between the pattern separation and the volumes of hippocampal subfields in humans remain unknown. Methods 58 young adults were examined the memory task (pattern separation, pattern completion) and the hippocampal volumes. Subjects were asked to determine whether the visual image is a new stimulus, or a similar but different stimulus (pattern separation), or the same stimulus (pattern completion), compared to preceding stimuli, and response time and correct response were measured. The volumes of the whole brain, hippocampus 6 subfields and perihippocampus 5 subfields, were measured using FreeSurfer 6.0. Results Negative associations between the pattern separation task and the volumes of whole brain areas were found in bilateral cerebellar cortex, fourth ventricle, left hippocampus, left thalamus, left ventral diencephalon, and brainstem. Simple linear regression analysis revealed a significant association with the left hippocampal‐amygdaloid transition area only, while no significant associations were found in any of the subfield volumes when adjusted with covariates. Conclusions The principle “bigger is better”—an idea that the larger the volume the better the function—could not be applied to the relation between the pattern separation ability and the dentate gyrus. The pattern separation ability which distinguishes similar but different stimuli is the kernel of our memory. The novelty and the social significance lies in its evaluation of the associations between the pattern separation ability related to neurogenesis and the volumes of the subfields including the dentate gyrus of the hippocampus in healthy young adults. There were no significant causal associations when adjusted with covariates.