牛和猪肌肉组织中安乃近代谢物残留的液相色谱-串联质谱分析
建立了牛和猪肌肉组织中安乃近代谢残留物4-甲酰氨基安替比林、4-乙酰氨基安替比林、4-氨基安替比林和4-甲基氨基安替比林的高效液相色谱-串连质谱（LC-M／MS）测定法。肌肉组织样品均质后，采用硫酸钠提取液提取。过滤后，过C18固相萃取（SPE）柱净化，采用LC-MS／MS电喷雾电离（ESI），多反应监测（MRM）模式检测。4-甲酰氨基安替比林和4-乙酰氨基安替比林采用外标法定量，而4-甲基氨基安替比林和4-氨基安替比林则是以4-异丙基氨基安替比林作为内标物采用内标法进行定量；4-甲酰氨基安替比林和4-氨基安替比林的检出限为1．0μ∥L；4-乙酰氨基安替比林和4-甲基氨基安替比林的检出限则为0...
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| Published in | Fēnxī huàxué Vol. 35; no. 11; pp. 1565 - 1569 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
深圳出入境检验检疫局食品检验与检疫技术中心,深圳,518067%秦皇岛出入境检验检疫局,秦皇岛,066002
2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | 建立了牛和猪肌肉组织中安乃近代谢残留物4-甲酰氨基安替比林、4-乙酰氨基安替比林、4-氨基安替比林和4-甲基氨基安替比林的高效液相色谱-串连质谱（LC-M／MS）测定法。肌肉组织样品均质后，采用硫酸钠提取液提取。过滤后，过C18固相萃取（SPE）柱净化，采用LC-MS／MS电喷雾电离（ESI），多反应监测（MRM）模式检测。4-甲酰氨基安替比林和4-乙酰氨基安替比林采用外标法定量，而4-甲基氨基安替比林和4-氨基安替比林则是以4-异丙基氨基安替比林作为内标物采用内标法进行定量；4-甲酰氨基安替比林和4-氨基安替比林的检出限为1．0μ∥L；4-乙酰氨基安替比林和4-甲基氨基安替比林的检出限则为0．5μg／L；在添加浓度为5～200ng／g范围内，4-甲酰氨基安替比林的同收率为81．6％～94．0％；4-乙酰氨基安替比林的回收率为81．2％～90．2％；4-氨基安替比林的同收率为82％～101％；4-甲基氨基安替比林的回收率为78．5％～87．0％；相对标准偏差（RSD）均在7％以内。 |
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| AbstractList | O6; 建立了牛和猪肌肉组织中安乃近代谢残留物4-甲酰氨基安替比林、4-乙酰氨基安替比林、4-氢基安替比林和4-甲基氨基安替比林的高效液相色谱-串连质谱(LC-M/MS)测定法.肌肉组织样品均质后,采用硫酸钠提取液提取.过滤后,过C18固相萃取(SPE)柱净化,采用LC-MS/MS电喷雾电离(ESI),多反应监测(MRM)模式检测.4-甲酰氨基安替比林和4-乙酰氨基安替比林采用外标法定量,而4-甲基氨基安替比林和4-氨基安替比林则是以4-异丙基氨基安替比林作为内标物采用内标法进行定量;4-甲酰氨基安替比林和4-氨基安替比林的检出限为1.0μg/L;4-乙酰氨基安替比林和4-甲基氨基安替比林的检出限则为0.5μg/L;在添加浓度为5～200 ng/g范围内,4-甲酰氨基安替比林的回收率为81.6%～94.0%;4-乙酰氨基安替比林的回收率为81.2%～90.2%;4-氨基安替比林的回收率为82%～101%;4-甲基氨基安替比林的回收率为78.5%～87.0%;相对标准偏差(RSD)均在7%以内. 建立了牛和猪肌肉组织中安乃近代谢残留物4-甲酰氨基安替比林、4-乙酰氨基安替比林、4-氨基安替比林和4-甲基氨基安替比林的高效液相色谱-串连质谱（LC-M／MS）测定法。肌肉组织样品均质后，采用硫酸钠提取液提取。过滤后，过C18固相萃取（SPE）柱净化，采用LC-MS／MS电喷雾电离（ESI），多反应监测（MRM）模式检测。4-甲酰氨基安替比林和4-乙酰氨基安替比林采用外标法定量，而4-甲基氨基安替比林和4-氨基安替比林则是以4-异丙基氨基安替比林作为内标物采用内标法进行定量；4-甲酰氨基安替比林和4-氨基安替比林的检出限为1．0μ∥L；4-乙酰氨基安替比林和4-甲基氨基安替比林的检出限则为0．5μg／L；在添加浓度为5～200ng／g范围内，4-甲酰氨基安替比林的同收率为81．6％～94．0％；4-乙酰氨基安替比林的回收率为81．2％～90．2％；4-氨基安替比林的同收率为82％～101％；4-甲基氨基安替比林的回收率为78．5％～87．0％；相对标准偏差（RSD）均在7％以内。 |
| Author | 沈金灿 庞国芳 谢丽琪 林燕奎 陈沛金 韩瑞阳 |
| AuthorAffiliation | 深圳出入境检验检疫局食品检验与检疫技术中心,深圳518067 秦皇岛出入境检验检疫局,秦皇岛066002 |
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| Author_FL | Chen Pei-Jin Pang Guo-Fang Shen Jin-Can Xie Li-Qi Han Rui-Yang Lin Yan-Kui |
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| Keywords | 质谱 液相色谱 代谢物 安乃近 |
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| Title | 牛和猪肌肉组织中安乃近代谢物残留的液相色谱-串联质谱分析 |
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