进展性肝纤维化与2型糖尿病周围神经病变的关系
目的研究进展性肝纤维化与2型糖尿病周围神经病变(DPN)之间的关系。方法选取近3年(2013年2月一2015年2月)在天津市第三中心医院住院的2型糖尿病(T2DM)患者173例(男89例,女84例),根据非酒精性脂肪性肝病纤维化评分(NFS)分为3组:A组(NFS≤一1.455)49例,B组(一1.455〈NFS〈0.676)95例,c组(NFs≥0.676)29例。比较3组DPN、感觉神经病变(SNCA)和运动神经病变(MNCA)的发生率,并分析3种疾病的影响因素。DPN、SNCA和MNCA由神经电图确诊,肝纤维化严重程度由NFS确定。结果A、B、c组患者DPN、SNCA、MNCA的发生率分...
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Published in | 天津医药 Vol. 44; no. 3; pp. 345 - 348 |
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Main Author | |
Format | Journal Article |
Language | Chinese |
Published |
天津医科大学三中心临床学院 邮编300170%天津市第三中心医院 天津市人工细胞重点实验室
2016
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Subjects | |
Online Access | Get full text |
ISSN | 0253-9896 |
DOI | 10.11958/20150105 |
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Summary: | 目的研究进展性肝纤维化与2型糖尿病周围神经病变(DPN)之间的关系。方法选取近3年(2013年2月一2015年2月)在天津市第三中心医院住院的2型糖尿病(T2DM)患者173例(男89例,女84例),根据非酒精性脂肪性肝病纤维化评分(NFS)分为3组:A组(NFS≤一1.455)49例,B组(一1.455〈NFS〈0.676)95例,c组(NFs≥0.676)29例。比较3组DPN、感觉神经病变(SNCA)和运动神经病变(MNCA)的发生率,并分析3种疾病的影响因素。DPN、SNCA和MNCA由神经电图确诊,肝纤维化严重程度由NFS确定。结果A、B、c组患者DPN、SNCA、MNCA的发生率分别为69.4%、78.9%、86.2%,65.3%、73.7%、86.2%和38.8%、49.5%、65.5%,组间差异均无统计学意义。Logistic回归分析示高NFS为DPN、SNCA、MNCA的独立危险因素。结论非酒精性脂肪性肝病导致的肝纤维化与DPN发生率的增加有关,高NFS是导致T2DM患者发生DPN、SNCA、MNCA的独立危险因素。 |
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Bibliography: | Objective To study the relationship between advanced liver fibrosis and peripheral neuropathy in patientswith type 2 diabetes mellitus(DPN). Methods A total of 173 patients(89 men and 84 women) with type 2 diabetes who hos-pitalized in Tianjin Third Central Hospital within nearly three years(2013.02-2015.02) were divided into three groups ac-cording to non-alcoholic fatty liver disease(NAFLD) fibrosis score: group A(NFS≤-1.455), group B(-1.455NFS0.676)and group C(NFS≥0.676). The prevalence of DPN, sensory nerve conduction abnormalities(SNCA), motor nerve conductionabnormalities(MNCA) were compared, and the influencing factors were analysis between three groups. DPN, MNCA and SN-CA were ascertained by electroneurogram, and the severity of liver fibrosis was ascertained by NAFLD fibrosis score. Results The prevalence rates of DPN, SNCA and MNCA were 69.4%, 78.9%, 86.2%, 65.3%, 73.7%, 86.2%, 38.8%, 49.5%and 65.5% in group A, group B and group C. There was no significant statistical difference between the three g |
ISSN: | 0253-9896 |
DOI: | 10.11958/20150105 |