Insulin resistance and atherosclerosis

Considerable evidence supports the association between insulin resistance and vascular disease, and this has led to wide acceptance of the clustering of hyperlipidemia, glucose intolerance, hypertension, and obesity as a clinical entity, the metabolic syndrome. While insulin resistance, by promoting...

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Published inThe Journal of clinical investigation Vol. 116; no. 7; pp. 1813 - 1822
Main Author Semenkovich, Clay F
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.07.2006
Subjects
Adipocytes
Animals
Apolipoproteins
Atherosclerosis
Atherosclerosis - physiopathology
Atherosclerosis - therapy
Biomedical research
Cardiovascular disease
Cell Nucleus - metabolism
Cholesterol
Diabetes
Dyslipidemias - physiopathology
Endoplasmic Reticulum - metabolism
Enzymes
Fatty acids
Genotype & phenotype
Glucose
High density lipoprotein
Humans
Hyperglycemia
Hyperglycemia - physiopathology
Hypertension
Hypertension - physiopathology
Insulin Resistance
Lipids
Lipoproteins
Medical research
Medicine, Experimental
Metabolic disorders
Metabolic syndrome
Mitochondria - metabolism
Obesity
Oxidative Stress
Peroxisome Proliferator-Activated Receptors - metabolism
Proteins
Review Series
Triglycerides
Missouri
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Summary:Considerable evidence supports the association between insulin resistance and vascular disease, and this has led to wide acceptance of the clustering of hyperlipidemia, glucose intolerance, hypertension, and obesity as a clinical entity, the metabolic syndrome. While insulin resistance, by promoting dyslipidemia and other metabolic abnormalities, is part of the proatherogenic milieu, it is possible that insulin resistance itself in the vascular wall does not promote atherosclerosis. Recent findings suggest that insulin resistance and atherosclerosis could represent independent and ultimately maladaptive responses to the disruption of cellular homeostasis caused by the excess delivery of fuel.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI29024