Synthesis and application of magnetic@layered double hydroxide as an anti-inflammatory drugs nanocarrier

• Published in: Journal of nanobiotechnology Vol. 18; no. 1; pp. 1 - 11
• Main Authors: Yousefi, Vahid, Tarhriz, Vahideh, Eyvazi, Shirin, Dilmaghani, Azita
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 29.10.2020; BioMed Central; BMC
• Subjects: Aluminum; Anion exchanging; Antacids; Anti-inflammatory agents; Anti-inflammatory drugs; Biocompatibility; Brucite; Cations; Chemical properties; Core-shell structure; Cytotoxicity; Diclofenac; Drug delivery; Drug delivery systems; Drugs; Health aspects; Hydroxides; Ibuprofen; Inflammation; Iron oxide nanoparticle; Iron oxides; Layered double hydroxide; Lipophilicity; Magnesium; Magnesium hydroxide; Magnetic materials; Magnetic properties; Materials; Morphology; Nanocomposites; Nanomaterials; Nanoparticles; Nanospheres; Nanostructure; Nitrates; Nonsteroidal anti-inflammatory drugs; Production processes; Spectrum analysis; Strong interactions (field theory); Synthesis; Thermal stability; Iran
• ISSN: 1477-3155; 1477-3155
• DOI: 10.1186/s12951-020-00718-y

Magnetic nanocomposites with a core-shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier. Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. The Fe.sub.3O.sub.4@LDH-ibuprofen and Fe.sub.3O.sub.4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe.sub.3O.sub.4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.