Interaction effect between the BDNF Val66Met polymorphism and parental rearing for interpersonal sensitivity in healthy subjects

• Published in: Psychiatry research Vol. 200; no. 2-3; pp. 945 - 948
• Main Authors: Suzuki, Akihito, Matsumoto, Yoshihiko, Shibuya, Naoshi, Ryoichi, Sadahiro, Kamata, Mitsuhiro, Enokido, Masanori, Goto, Kaoru, Otani, Koichi
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 30.12.2012; Elsevier
• Subjects: Adolescent; Adult; Asian Continental Ancestry Group - genetics; BDNF Val66Met polymorphism; Biological and medical sciences; Brain-Derived Neurotrophic Factor - genetics; Couple and family; Female; Fundamental and applied biological sciences. Psychology; Gene×environment interaction; Genotype; Humans; Interpersonal Relations; Interpersonal sensitivity; Japan; Male; Maternal Behavior; Middle Aged; Object Attachment; Parenting; Parents; Personality traits; Personality. Affectivity; Polymorphism, Single Nucleotide; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Social psychology; Japan; Parenting; Gene×environment interaction; BDNF Val66Met polymorphism; Interpersonal sensitivity; Social environment; Human; Parental behavior; Healthy subject; Gene x environment interaction; Environmental factor; Personality; Genetic determinism; Genotype environment interaction; Social interaction; Family environment; Genetics; Brain derived neurotrophic factor; Interpersonal relation; Polymorphism
• ISSN: 0165-1781; 1872-7123; 1872-7123
• DOI: 10.1016/j.psychres.2012.03.014

Interpersonal sensitivity is defined as undue and excessive awareness of, and sensitivity to, the behaviour and feelings of others and is one of the vulnerable factors to depression. In a twin study, it was suggested that this personality trait was characterised by both genetic and environmental factors. In the present study, we examined the effects of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and parental rearing on interpersonal sensitivity in 725 healthy Japanese subjects. Assessment of interpersonal sensitivity was performed by the Japanese version of the Interpersonal Sensitivity Measure (IPSM). Perceived parental rearing was assessed by the Parental Bonding Instrument (PBI), which consists of the care and protection factors. The BDNF polymorphism was detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. There was no main effect of the BDNF genotype on the IPSM score, while the PBI factors except maternal care had significant main effect on the IPSM score. There was significant interaction effect between the BDNF genotype and maternal care of the PBI on the IPSM score. Post-hoc analysis of simple slopes showed that the negative relationship between the IPSM score and maternal care was strongest and significant in the Met/Met genotype group, intermediate in the Val/Met genotype group and weakest in the Val/Val genotype group. The present study suggests that the interaction between the BDNF Val66Met polymorphism and parental rearing, especially maternal care, influences interpersonal sensitivity in healthy subjects.