COVID-19: A promising cure for the global panic

• Published in: The Science of the total environment Vol. 725; p. 138277
• Main Authors: Vellingiri, Balachandar, Jayaramayya, Kaavya, Iyer, Mahalaxmi, Narayanasamy, Arul, Govindasamy, Vivekanandhan, Giridharan, Bupesh, Ganesan, Singaravelu, Venugopal, Anila, Venkatesan, Dhivya, Ganesan, Harsha, Rajagopalan, Kamarajan, Rahman, Pattanathu K.S.M., Cho, Ssang-Goo, Kumar, Nachimuthu Senthil, Subramaniam, Mohana Devi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.07.2020
• Subjects: Betacoronavirus; Coronavirus disease 2019 (COVID-19); Coronavirus Infections; COVID-19; diagnostic techniques; drugs; etiological agents; globalization; health services; hospitals; human diseases; Humans; immune response; Indian traditional medicine; influenza; Mechanism of action; medicinal plants; Orthocoronavirinae; pandemic; Pandemics; Pneumonia, Viral; public health; Review; risk assessment; SARS-CoV-2; Therapeutic approach; therapeutics; viruses; RTC; TMPRSS11a; TNFβ; FDA; MCP-1; ORF; RCT; RNA; SARS-COV-2; JNK; NF-kB; CNS; Indian traditional medicine; FP; MERS-CoV; mRNA; Therapeutic approach; PHEV; COVID-19; ASC; TRS; RBD; ACE2-Fc; RdRp; NLRP3; MHV; RBM; Mechanism of action; ARDS; WHO; HCoV; JAK-STAT; SARS; NIH; ER; PHEIC; ACE2; ADAM17; ExoN; HIV; TRAF3; ROS; TM; MERS; Coronavirus disease 2019 (COVID-19); SARS-CoV-2
• ISSN: 0048-9697; 1879-1026; 1879-1026
• DOI: 10.1016/j.scitotenv.2020.138277

The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. [Display omitted] •SARS-COV-2 is structurally similar to SARS-COV.•The mechanism of SARS-COV-2 in the host cell may be comparable to SARS-COV.•SARS-CoV-2 invade the immune and nervous system.•There is an urgent need for novel treatment options for COVID-19.•Indian medicinal plants are likely to be potential drugs for the treatment of COVID-19.