The therapeutic effects of autologous conditioned serum on knee osteoarthritis: an animal model

• Published in: BMC research notes Vol. 15; no. 1; pp. 1 - 277
• Main Authors: Pishgahi, Alireza, Zamani, Majid, Mehdizadeh, Amir, Roshangar, Leila, Afkham-Daghdaghan, Milad, Pourabbas, Behzad, Yousefi, Mehdi
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 12.08.2022; BioMed Central; BMC
• Subjects: Animal models; Animals; Arthritis; Autologous conditioned serum; Biological products; Carbon; Carbon dioxide; Care and treatment; Cartilage; Chronic illnesses; Coatings; Cytokines; Development and progression; Epidermal growth factor; Flexibility; Glass beads; Growth factors; Health aspects; Inflammation; Insulin-like growth factors; Intravenous administration; Knee; Medical research; Medicine, Experimental; Mobility; Osteoarthritis; Pathogenesis; Research Note; Syringes; Tumor necrosis factor-TNF; Iran
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-022-06166-1

As a progressive chronic condition, osteoarthritis (OA) causes substantial pain and impairment. Secrete proinflammatory cytokines are essential mediators involved in the pathophysiology of OA. In this regard, the clinical effectiveness of autologous conditioned serum (ASC) has been shown through its injection into OA tissues. This study aimed to assess the effectiveness and concentration level of ACS components produced by Nano-carbon glass beads. Glass beads-prepared ACS coated with Nano-carbon, induced a huge amount of cytokines and growth factors production. The concentration level of anti-inflammatory cytokines and proinflammatory cytokines was improved throughout Nano-carbon coated glass beads stimulation. ACS also shortened the recovery time and improved the function and mobility of OA rabbits.