Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population

• Published in: Environmental research Vol. 135; pp. 247 - 252
• Main Authors: Zhang, Xuhui, Liu, Yi, Zhang, Lei, Yang, Zhangping, Shao, Yuxian, Jiang, Caixia, Wang, Qiang, Fang, Xinyan, Xu, Yuyang, Wang, Hao, Zhang, Shuai, Zhu, Yimin
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.2014; Elsevier
• Subjects: Adjustment; Age Factors; Alcohol Drinking; Arrays; Biological and medical sciences; Cadherins - genetics; China - epidemiology; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Exposure; Female; Gene Frequency; Genetic Association Studies; Genetic susceptibility; Genetics; Genotype; Hearing; Hearing Loss, Noise-Induced - epidemiology; Hearing Loss, Noise-Induced - genetics; Humans; Logistic Models; Male; Medical sciences; Nanostructure; Noise; Noise exposure; Non tumoral diseases; Occupational Exposure; Occupational medicine; Odds Ratio; Otorhinolaryngology. Stomatology; Polymorphism, Single Nucleotide - genetics; Protocadherin 15/PCDH15; Public health. Hygiene-occupational medicine; Risk; Single-nucleotide polymorphism/SNP; Smoking; Asia; China; Protocadherin 15/PCDH15; Noise exposure; Genetic susceptibility; Single-nucleotide polymorphism/SNP; Human; Genetic variability; Noise; Auditory disorder; Genotype; Occupational exposure; Hearing loss; Protocadherin 1S/PCDH15; ENT disease; Single nucleotide polymorphism; Occupational medicine
• ISSN: 0013-9351; 1096-0953
• DOI: 10.1016/j.envres.2014.09.021

Objectives: The purpose of this study was to examine the associations between genetic variations in the Protocadherin 15 gene (PCDH15) and the risk to noise induced hearing loss (NIHL) in a Chinese population. Methods: A case-control study was conducted with 476 noise-sensitive workers (NIHL) and 475 noise-resistant workers (normal) matched for gender, years of noise exposure, and intensity of noise exposure. 13 tag single-nucleotide polymorphisms in PCDH15 were genotyped using nanofluidic dynamic arrays on the Fluidigm platform. Multiple logistic regression was used to analyze the associations of genetic variations of PCDH15 with NIHL adjusted by age, smoking/drinking status, and cumulative noise exposure and their interactions with noise exposure. Results: The allele frequency and genotypes of rs1104085 were significantly associated with the risk of NIHL(P=0.009 and 0.005 respectively ). The subjects carrying variant alleles (CT or CC) of rs11004085 had a decreased the risk for NIHL (adjusted odds ratio=0.587, 95% confidence interval 0.409–0.842) compared with subjects who had the wild-type (TT) homozygotes. The interactions were found between the SNPs of rs1100085, rs10825122, rs1930146, rs2384437, rs4540756, and rs2384375 and noise exposure. Conclusions: Genetic variations of PCDH15 and their interactions with occupational noise exposure are associated with genetic susceptibility to NIHL and modify the risk of noise induced hearing loss. •We examined the associations of 13 SNPs of Protocadherin 15 gene with noise-induced hearing loss (NIHL).•SNPs of Protocadherin 15 gene associated with the NIHL.•There were interactions between genetic variations of Protocadherin 15 and noise exposure•Genetic variations of Protocadherin 15 might modify the risk of NIHL.