Sheep scab: comparison of spatial and temporal patterns determined by clinical diagnosis or ELISA

• Published in: Parasites & vectors Vol. 15; no. 1; pp. 1 - 419
• Main Authors: Makepeace, Chloe, Nixon, Emily Joanne, Burgess, Stewart T. G, Stubbings, Lesley, Wall, Richard
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 11.11.2022; BioMed Central; BMC
• Subjects: Agriculture; Allergens; Animal diseases; Diagnosis; Disease; Economic impact; ELISA; Enzyme-linked immunosorbent assay; Enzymes; Epidemics; Farmers; Farms; Health aspects; History; Hypersensitivity; Infestation; Inspection; Livestock farms; Mite; Monte Carlo simulation; Outbreaks; Pest outbreaks; Prevalence; Psoroptes ovis; Questionnaires; Regions; Scabies; Serology; Sheep; Sheep scab; Skin diseases; Spatial analysis; Statistics; Testing; United Kingdom; United Kingdom > UK; England
• ISSN: 1756-3305; 1756-3305
• DOI: 10.1186/s13071-022-05564-5

Ovine psoroptic mange (sheep scab) is an infectious condition caused by an allergen-induced hypersensitivity response to the mite Psoroptes ovis. Infestation results in clinical disease, economic loss and welfare issues in many sheep-producing countries. The aim of this study was to compare the prevalence and spatial pattern of sheep scab on contiguous farms, using both self-reported clinical outbreak history (2012-2020) and serological testing with an enzyme-linked immunosorbent assay (2021/2022). Farms included in the study were located in three regions of known high scab prevalence in North, Central and Southwest England. In total, 254 farms completed both a questionnaire, which provided the clinical scab history of the farm, and submitted results of serological testing with the ELISA. A scab outbreak was reported by 17.4% ([+ or -] confidence interval [CI]: 4.6%; n = 48) of farms in 2020 based on clinical diagnosis; scab was diagnosed by the ELISA on 25.6% ([+ or -] 5.5%; n = 65) of farms in 2021/2022. Comparison of self-reported clinical scab cases with the ELISA test results identified a group of farms (n = 52) that did not report scab in 2020, or in some cases did not report having scab over the previous 8 years (n = 20), but whose flocks were nevertheless seropositive in 2021/2022. A small number of flocks, particularly those using common grazings in North England, where handling is infrequent, often comprising less susceptible sheep breeds, may have persistent scab infestations that are generally undetected by clinical inspection. The data highlight the advantages of serological testing to identify exposure to scab in flocks where clinical signs are less easily detected.