What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?

• Published in: Neurocritical care Vol. 32; no. 1; pp. 306 - 310
• Main Authors: Helbok, Raimund, Hartings, Jed A., Schiefecker, Alois, Balança, Baptiste, Jewel, Sharon, Foreman, Brandon, Ercole, Ari, Balu, Ramani, Ayata, Cenk, Ngwenya, Laura, Rosenthal, Eric, Boutelle, Martyn G., Farkas, Eszter, Dreier, Jens P., Fabricius, Martin, Shuttleworth, C. William, Carlson, Andrew
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2020; Springer Nature B.V; Springer
• Subjects: Brain Injuries, Traumatic - drug therapy; Brain Injuries, Traumatic - physiopathology; Brain research; Cortical Spreading Depression; Critical Care Medicine; Drug dosages; Electrocorticography; Electroencephalography; Excitatory Amino Acid Antagonists - therapeutic use; Hemorrhage; Humans; Intensive; Internal Medicine; Ischemia; Ketamine; Ketamine - therapeutic use; Life Sciences; Medicine; Medicine & Public Health; Neurobiology; Neurology; Neurons and Cognition; Outcome Assessment, Health Care; Patients; Physiology; Precision Medicine; Proceedings; Stroke; Stroke - drug therapy; Stroke - physiopathology; Subarachnoid Hemorrhage - drug therapy; Subarachnoid Hemorrhage - physiopathology; Trauma; Traumatic brain injury; Traumatic brain injury; Subarachnoid hemorrhage; Cortical spreading depression; Outcome; Ischemic Stroke; Electroencephalography; Intracerebral hemorrhage
• ISSN: 1541-6933; 1556-0961
• DOI: 10.1007/s12028-019-00777-6

The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading depolarizations are observed in a patient?” Discussants represented a wide range of expertise, including neurologists, neurointensivists, neuroradiologists, neurosurgeons, and pre-clinical neuroscientists, to provide both clinical and basic pathophysiology perspectives. A draft summary of viewpoints offered was then written by a multidisciplinary writing group of iCSD members, based on a transcript of the session. Feedback of all discussants was formally collated, reviewed, and incorporated into the final document which was subsequently approved by all authors.