Expression of E- and N-cadherin and CD44 in endometrium and hydrosalpinges from infertile women

• Published in: Fertility and sterility Vol. 94; no. 7; pp. 2909 - 2912
• Main Authors: Poncelet, Christophe, M.D., Ph.D, Cornelis, Françoise, M.D, Tepper, Maryline, Sauce, Emmanuel, Magan, Nathalie, Wolf, Jean Philippe, M.D., Ph.D, Ziol, Marianne, M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2010; Elsevier
• Subjects: Antigens, CD - metabolism; Atrophy - metabolism; Biological and medical sciences; Biopsy; cadherins; Cadherins - metabolism; Case-Control Studies; CD44; embryo implantation; Endometrium; Endometrium - metabolism; Endometrium - pathology; Fallopian Tube Diseases - metabolism; Fallopian Tube Diseases - pathology; Fallopian Tubes - metabolism; Fallopian Tubes - pathology; Female; Gynecology. Andrology. Obstetrics; Humans; Hyaluronan Receptors - metabolism; hydrosalpinx; Infertility, Female - metabolism; Infertility, Female - pathology; Internal Medicine; Medical sciences; Obstetrics and Gynecology; hydrosalpinx; cadherins; Endometrium; CD44; embryo implantation; Embryo; N-cadherin; Hydrosalpinx; Gynecology; Implantation; Female sterility; E Cadherin; Obstetrics
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2010.04.055

In this prospective comparative study, compared with fertile control subjects (n = 12), infertile patients with hydrosalpinx (n = 18) had lower E-cadherin and a trend toward decreased N-cadherin H-scores in the endometrium (3.6 ± 0.6 vs. 2.4 ± 0.8 and 0.57 ± 1.0 vs. 0.52 ± 0.5, respectively). In hydrosalpinx, epithelial N-cadherin expression was discontinuous and disappeared in atrophic patches.