Neurocognitive impacts of arbovirus infections

• Published in: Journal of neuroinflammation Vol. 17; no. 1; pp. 1 - 233
• Main Authors: Cle, Marion, Eldin, Patrick, Briant, Laurence, Lannuzel, Annie, Simonin, Yannick, Van de Perre, Philippe, Cabie, Andre, Salinas, Sara
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 10.08.2020; BioMed Central; BMC
• Subjects: Arbovirus; Arbovirus diseases; Central nervous system; Central nervous system diseases; Cognition; Cognitive ability; Cognitive disorders; Cognitive Sciences; Complications and side effects; Congenital defects; Congenital diseases; Cytomegalovirus; Dementia; Development and progression; Encephalitis; Epidemics; Fever; Hemorrhage; Hemorrhagic fever; HIV; Human health and pathology; Human immunodeficiency virus; Immune system; Infections; Infectious diseases; Inflammation; Life Sciences; Long-term sequelae; Meningitis; Nervous system; Neurobiology; Neurological diseases; Neurons and Cognition; Neuropathology; Paralysis; Pathology; Public health; Quality of life; Review; Risk factors; Viruses; West Nile virus; France; Nervous system; Arbovirus; Long-term sequelae; Cognition Background
• ISSN: 1742-2094; 1742-2094
• DOI: 10.1186/s12974-020-01904-3

Arthropod-borne viruses or arbovirus, are most commonly associated with acute infections, resulting on various symptoms ranging from mild fever to more severe disorders such as hemorrhagic fever. Moreover, some arboviral infections can be associated with important neuroinflammation that can trigger neurological disorders including encephalitis, paralysis, ophthalmological impairments, or developmental defects, which in some cases, can lead to long-term defects of the central nervous system (CNS). This is well illustrated in Zika virus-associated congenital brain malformations but also in West Nile virus-induced synaptic dysfunctions that can last well beyond infection and lead to cognitive deficits. Here, we summarize clinical and mechanistic data reporting on cognitive disturbances triggered by arboviral infections, which may highlight growing public health issues spanning the five continents.