Optical coherence tomography angiography in preclinical neuroimaging

• Published in: Biomedical engineering letters Vol. 9; no. 3; pp. 311 - 325
• Main Author: Choi, Woo June
• Format: Journal Article
• Language: English
• Published: Korea The Korean Society of Medical and Biological Engineering 01.08.2019; Springer Nature B.V; 대한의용생체공학회
• Subjects: Aging; Angiography; Animal models; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Blood flow; Blood vessels; Brain; Brain research; Coherent scattering; Contrast agents; Engineering; Erythrocytes; Head injuries; Image resolution; Laboratory animals; Medical and Radiation Physics; Medical imaging; Neural networks; Neuroimaging; Neurology; Optical Coherence Tomography; Review; Review Article; Tomography; Traumatic brain injury; 의공학; Traumatic brain injury, stroke, aging; Optical coherence tomography; Angiography; Preclinical neuroimaging, small animal models
• ISSN: 2093-9868; 2093-985X
• DOI: 10.1007/s13534-019-00118-8

Preclinical neuroimaging allows for the assessment of brain anatomy, connectivity, and function in laboratory animals, such as mice and this imaging field has been a rapidly growing aimed at bridging the translation gap between animal and human research. The progress in the animal research could be accelerated by high-resolution in vivo optical imaging technologies. Optical coherence tomography-based angiography (OCTA) estimates the scattering from moving red blood cells, providing the visualization of functional micro-vessel networks within tissue beds in vivo without a need for exogenous contrast agents. Recent advancement of OCTA methods have expanded its application to neuroimaging of small animal models of brain disorders. In this paper, we overview the recent development of OCTA techniques for blood flow imaging and its preclinical applications in neuroimaging. In specific, a summary of preclinical OCTA studies for traumatic brain injury, cerebral stroke, and aging brain on mice is reviewed.