Biomechanical consequences of the intervertebral disc centre of rotation kinematics during lateral bending and axial rotation

• Published in: Scientific reports Vol. 13; no. 1; pp. 3172 - 13
• Main Authors: Allais, Roman, Capart, Antoine, Da Silva, Anabela, Boiron, Olivier
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.02.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 639/166/985; 639/166/988; 692/698/1671/1354; Animals; Biomechanical Phenomena - physiology; Biomechanics; Humanities and Social Sciences; Intervertebral Disc - surgery; Intervertebral discs; Kinematics; Lactic acid; Lumbar Vertebrae - surgery; Mechanics; multidisciplinary; Patient-Specific Modeling; Physics; Prosthetics; Range of Motion, Articular - physiology; Science; Science (multidisciplinary); Swine; Finite element method; Intervertebral disc; Instantaneous centre of rotation
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-29551-7

The location of the instantaneous centre of rotation (ICR) of a lumbar unit has a considerable clinical importance as a spinal health estimator. Consequently, many studies have been conducted to measure or estimate the ICR during rotations in the three anatomical planes; however the results reported are widely scattered. Even if some inter-subjects variability is to be expected, such inconsistencies are likely explained by the differences in methods and experiments. Therefore, in this paper we seek to model three behaviours of the ICR during lateral bending and axial rotation based on results published in the literature. In order to assess the metabolic and mechanical sensibility to the assumption made on the ICR kinematics, we used a previously validated three dimensional non-linear poroelastic model of a porcine intervertebral disc to simulate physiological lateral and axial rotations. The impact of the geometry was also briefly investigated by considering a 11 ∘ wedge angle. From our simulations, it appears that the hypothesis made on the ICR location does not significantly affect the critical nutrients concentrations but gives disparate predictions of the intradiscal pressure at the centre of the disc (variation up to 0.7 MPa) and of the displacement fields (variation up to 0.4 mm). On the contrary, the wedge angle does not influence the estimated intradiscal pressure but leads to minimal oxygen concentration decreased up to 33% and increased maximal lactate concentration up to 13%. While we can not settle on which definition of the ICR is more accurate, this work suggests that patient-specific modeling of the ICR is required and brings new insights that can be useful for the development of new tools or the design of surgical material such as total lumbar disc prostheses.