Dual-modal in vivo assessment for electrophysical and hemodynamic characteristics of cerebral edema induced by lipopolysaccharide

• Published in: Biomedical engineering online Vol. 21; no. 1; pp. 1 - 79
• Main Authors: Li, Weitao, Zhang, Yameng, Xie, Qian, Qi, Xinping, Yao, Liuye, Ning, Xue, Qian, Zhiyu
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 21.11.2022; BioMed Central; BMC
• Subjects: Blood flow; Brain research; Cerebral blood flow; Cerebral edema; Correlation coefficient; Correlation coefficients; Cytotoxicity; Development and progression; Diagnosis; Edema; Electrophysiological recording; Electrophysiology; Firing rate; Hemodynamic responses; Hemodynamics; Hemoglobin; Intracranial pressure; Ischemia; Laser speckle contrast imaging; Lipopolysaccharides; Monitoring; Neuro-electrophysiology; Optical–electrical joint system; Parameters; Pathogenesis; Spectrum signal; Traumatic brain injury; China
• ISSN: 1475-925X; 1475-925X
• DOI: 10.1186/s12938-022-01047-x

The pathological features of cerebral edema are complicated. The intracranial pressure (ICP) is regarded as the most important indicator for monitoring cerebral edema. Recently, multi-parameter has been used to explore the types and pathogenesis of cerebral edema and design effective treatment strategies. This research focused on investigating the characteristic of the cerebral edema induced by lipopolysaccharide (LPS) in rats by using simultaneous electrophysical and hemodynamic parameters. The results showed that neurophysiologic parameters (firing rate (FR) and the power spectrum of local field potential (LFP power)) and hemodynamic parameters (relative concentration of oxygenated hemoglobin ([DELA]C.sub.HbO2), relative concentration of deoxyhemoglobin [DELA]C.sub.HbR) and relative cerebral blood flow (rCBF)) were linearly correlated, and the Pearson's correlation coefficient was changed by pathological progression of cerebral edema induced by LPS. Furtherly, the treatment after two agents were observed successfully through these multi-parameters. Our findings revealed the relationship between neural activity and hemodynamic response during the progression of cerebral edema and provided a multi-parameter solution for cerebral edema functional monitoring and anti-edema drug efficacy evaluation.