Severe diarrhoea caused by highly ciprofloxacin-susceptible Campylobacter isolates

• Published in: Clinical microbiology and infection Vol. 15; no. 2; pp. 188 - 192
• Main Authors: Feodoroff, F.B.L., Lauhio, A.R., Sarna, S.J., Hänninen, M.-L., Rautelin, H.I.K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01.02.2009; Blackwell Publishing Ltd; Wiley-Blackwell
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Campylobacter coli; Campylobacter coli - drug effects; Campylobacter coli - isolation & purification; Campylobacter infections; Campylobacter Infections - microbiology; Campylobacter Infections - pathology; Campylobacter Infections - physiopathology; Campylobacter jejuni; Campylobacter jejuni - drug effects; Campylobacter jejuni - isolation & purification; Child; Child, Preschool; ciprofloxacin; Ciprofloxacin - pharmacology; Diarrhea - microbiology; Diarrhea - pathology; Diarrhea - physiopathology; diarrhoea; drug resistance; Feces - microbiology; Female; Finland; hospitalization; Humans; Infant; Infant, Newborn; Infectious diseases; Male; Medical sciences; microbial; Microbial Sensitivity Tests; Middle Aged; Pharmacology. Drug treatments; signs and symptoms; Surveys and Questionnaires; Young Adult; Europe; Finland; hospitalization; signs and symptoms; Campylobacter coli; Finland; Campylobacter infections; drug resistance; diarrhoea; microbial; Campylobacter jejuni; ciprofloxacin; Treatment resistance; Campylobacteraceae; Diarrhea; Hospitalization; Infection; Campylobacter infection; Symptomatology; Fluoroquinolone derivatives; Bacteriosis; Bacteria; Digestive diseases; Intestinal disease; Antibacterial agent; Ciprofloxacin; Quinolone derivatives
• ISSN: 1198-743X; 1469-0691; 1469-0691
• DOI: 10.1111/j.1469-0691.2008.02657.x

The impact of fluoroquinolone resistance of Campylobacter jejuni and Campylobacter coli isolates on the outcome of the disease in sporadic Campylobacter infections of Finnish individuals was studied. Questionnaires were sent, during a 6-month study period, to patients who were stool culture-positive for Campylobacter spp. In total, 192 returned questionnaires were analysed and assessed, together with the susceptibility data of the respective bacterial isolates. Only one (2%) of the domestic, but half of the imported, Campylobacter isolates were resistant to ciprofloxacin. Ciprofloxacin resistance was not associated with particularly severe infection. Instead, ciprofloxacin-susceptible Campylobacter isolates, as compared to ciprofloxacin-resistant isolates, showed a tendency to cause more severe infections, characterized by bloody stools and hospitalization.