Recent advances in molecular targeted therapy for metastatic renal cell carcinoma

• Published in: International journal of urology Vol. 16; no. 5; pp. 444 - 448
• Main Author: Mizutani, Yoichi
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.05.2009
• Subjects: Antineoplastic Agents - therapeutic use; Benzenesulfonates - therapeutic use; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - secondary; Humans; Indoles - therapeutic use; Kidney Neoplasms - drug therapy; Kidney Neoplasms - pathology; molecular targeted therapy; Niacinamide - analogs & derivatives; Phenylurea Compounds; Pyridines - therapeutic use; Pyrroles - therapeutic use; renal cell carcinoma; Sirolimus - analogs & derivatives; Sirolimus - therapeutic use; sorafenib; sunitinib; temsirolimus
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/j.1442-2042.2009.02277.x

Advanced renal cell carcinoma (RCC) is resistant to chemotherapy and radiotherapy. Immunotherapy is relatively effective against RCC. However, the response rate is approximately 15–20%. Therefore, new therapeutic approaches are necessary. Recently, molecular mechanisms responsible for the proliferation of RCC are identified, and molecular targeted therapy is developed. Bevacizumab, sorafenib, sunitinib, axitinib, temsirolimus, everolimus are promising molecular targeted therapeutic agents for metastatic RCC, and will be used widely in clinics in the near future. In addition, combination therapy with molecular targeted therapy and other therapies including immunotherapy may also be developed soon.