Polymeric Nanoparticles with ROS‐Responsive Prodrug and Platinum Nanozyme for Enhanced Chemophotodynamic Therapy of Colon Cancer

• Published in: Advanced science Vol. 7; no. 20; pp. 2001853 - n/a
• Main Authors: Hao, Ying, Chen, Yuwen, He, Xinlong, Yu, Yongyang, Han, Ruxia, Li, Yang, Yang, Chengli, Hu, Danrong, Qian, Zhiyong
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.10.2020; John Wiley and Sons Inc; Wiley
• Subjects: Cancer therapies; chemophotodynamic therapy; colon cancer; Colorectal cancer; Decomposition; Efficiency; Hypoxia; Lasers; Nanoparticles; Particle size; Photodynamic therapy; platinum nanozymes; Polyethylene glycol; polymeric nanoparticles; ROS‐responsive prodrugs; Spectrum analysis; ROS‐responsive prodrugs; polymeric nanoparticles; chemophotodynamic therapy; colon cancer; platinum nanozymes
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202001853

The combination of chemotherapy and photodynamic therapy (PDT) has promising potential in the synergistic treatment of cancer. However, chemotherapy and photodynamic synergistic therapy are impeded by uncontrolled chemotherapeutics release behavior, targeting deficiencies, and hypoxia‐associated poor PDT efficacy in solid tumors. Here, a platinum nanozyme (PtNP) loaded reactive oxygen species (ROS)‐responsive prodrug nanoparticle (CPT‐TK‐HPPH/Pt NP) is created to overcome these limitations. The ROS‐responsive prodrug consists of a thioketal bond linked with camptothecin (CPT) and photosensitizer‐2‐(1‐hexyloxyethyl)‐2‐devinyl pyropheophorbide‐a (HPPH). The PtNP in CPT‐TK‐HPPH/Pt NP can efficiently catalyze the decomposition of hydrogen peroxide (H2O2) into oxygen to relieve hypoxia. The production of oxygen can satisfy the consumption of HPPH under 660 nm laser irradiation to attain the on‐demand release of CPT and ensure enhanced photodynamic therapy. As a tumor diagnosis agent, the results of photoacoustic imaging and fluorescence imaging for CPT‐TK‐HPPH/Pt NP exhibit desirable long circulation and enhanced in vivo targeting. CPT‐TK‐HPPH/Pt NPs effectively inhibit tumor proliferation and growth in vitro and in vivo. CPT‐TK‐HPPH/Pt NP, with its excellent ROS‐responsive drug release behavior and enhanced PDT efficiency can serve as a new cancer theranostic agent, and will further promote the research of chemophotodynamic synergistic cancer therapy. The platinum nanozyme (PtNP) loaded reactive oxygen species‐responsive prodrug nanoparticle (CPT‐TK‐HPPH/Pt NP) which could achieve the “on‐demand” release of CPT and relieve hypoxia to enhance photodynamic therapy efficiency, exhibits desirable long circulation and effectively inhibits tumor proliferation and growth in vitro and in vivo, has great promising potential in chemophotodynamic synergistic cancer therapy.