Relationship between advanced glycation end-product accumulation in the skin and pulmonary function

• Published in: Journal of Physical Therapy Science Vol. 30; no. 3; pp. 413 - 418
• Main Authors: Kubo, Akira, Kato, Michitaka, Sugioka, Yosuke, Mitsui, Rie, Fukuhara, Nobuki, Nihei, Fumi, Takeda, Yoshihiko
• Format: Journal Article
• Language: English
• Published: Japan The Society of Physical Therapy Science 01.01.2018; Japan Science and Technology Agency
• Subjects: Advanced glycation end product; Elderly; FEV1/FVC; Older people; Original; Elderly; FEV1/FVC; Advanced glycation end product
• ISSN: 0915-5287; 2187-5626
• DOI: 10.1589/jpts.30.413

[Purpose] This study aimed to evaluate the relationship between advanced glycation end-product accumulation and pulmonary function in a general population with normal spirometry results. [Subjects and Methods] A total of 201 subjects (mean age, 56 ± 11 years; males, 58%) enrolled in this study. Subjects were classified into two groups (younger group [<65 years old] and elderly group [≥65 years old]). Skin autofluorescence was assessed as an estimate of advanced glycation end-product. Forced vital capacity and forced expiratory volume in one second were measured using a spirometer, and the forced expiratory volume in one second/forced vital capacity ratio (FEV1/FVC) was calculated. [Results] Skin autofluorescence was not an independent factor associated with FEV1/FVC in the younger group, but both skin autofluorescence and pack-years of smoking were significant independent factors associated with FEV1/FVC in the elderly group. [Conclusion] Advanced glycation end-product accumulation, assessed by skin autofluorescence, is an independent factor negatively associated with FEV1/FVC in elderly people with normal spirometry results.